Results 121 to 130 of about 4,333,581 (301)
IEEE AccessComputer vision is becoming an increasingly vital field, offering significant opportunities for real-world applications. Object counting is one of its core aspects, with increasing utilization across scientific fields involving objects of varying sizes ...
Phu Nguyen Phan Hai +2 more
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, 1997 In this paper, the technique of stacking, previously only used for supervised learning, is applied to unsupervised learning. Specifically, it is used for non-parametric multivariate density estimation, to combine finite mixture model and kernel density estimators.
Smyth, Padhraic, Wolpert, David
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Multiplicative Censoring: Estimation of a Density and its Derivatives under the Lp-Risk
Revstat Statistical Journal, 2013 We consider the problem of estimating a density and its derivatives for a sample of multiplicatively censored random variables. The purpose of this paper is to present an approach to this problem based on wavelets methods.
Mohammad Abbaszadeh +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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Smoothing methods in biometry: a historic review
GMS Medizinische Informatik, Biometrie und Epidemiologie, 2005 In Germany around 25 years ago nonparametric smoothing methods have found their way into statistics and with some delay also into biometry. In the early 1980's there has been what one might call a boom in theoretical and soon after also in computational ...
Schimek, Michael G.
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CoRRWe investigate the use of diffusion models as neural density estimators. The current approach to this problem involves converting the generative process to a smooth flow, known as the Probability Flow ODE. The log density at a given sample can be obtained by solving the ODE with a black-box solver.
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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