Results 161 to 170 of about 855,474 (292)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Glyphosate Adsorption on Metal-Organic Framework M₃(BTC)₂: Mechanistic Insights and Descriptors for the Adsorption Energy from Density Functional Calculations. [PDF]

ACS Omega
Putthabal A, Sukhonthachat S, Probst M, Thivasasith A, Limtrakul J, Maihom T.   +5 more
europepmc   +1 more source

Cooperativity of Spin Crossover Complexes: Combining Periodic Density Functional Calculations and Monte Carlo Simulation. [PDF]

Materials (Basel), 2017
Kreutzburg L, Hübner CG, Paulsen H.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Efficient Shift-and-Invert Preconditioning for Multi-GPU Accelerated Density Functional Calculations. [PDF]

J Chem Theory Comput
Woo J, Youn Kim W, Choi S.
europepmc   +1 more source

Density Functional Calculations for Prediction of ⁵⁷Fe Mössbauer Isomer Shifts and Quadrupole Splittings in β-Diketiminate Complexes. [PDF]

ACS Omega, 2017
McWilliams SF, Brennan-Wydra E, MacLeod KC, Holland PL.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Selenium Adsorption on the (111), (100), (110) and (211) surfaces of Face-Centered-Cubic Metals: Density Functional Calculations of the Potential Energy Surfaces. [PDF]

ChemistrySelect
Rivera RLA, Colon-Ruiz YL, De La Torre-Rosa A, Garcia-Ramos AI, Garcia-Sanchez AM, Gierbolini-Ortiz L, Lopez-Torres M, Ortiz-Rodriguez N, Rivera-Rivera VA, Santiago-Soler SC, Siberon-Albertorio JA, Silva-Burgos JN, Torres-Morales C, Santana JA.   +13 more
europepmc   +1 more source

Correction to "Density Functional Calculations for Prediction of ⁵⁷Fe Mossbauer Isomer Shifts and Quadrupole Splittings in β-Diketiminate Complexes". [PDF]

ACS Omega, 2017
McWilliams SF, Brennan-Wydra E, MacLeod KC, Holland PL.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source