Results 181 to 190 of about 6,241,670 (306)

Cooperativity of Spin Crossover Complexes: Combining Periodic Density Functional Calculations and Monte Carlo Simulation. [PDF]

Materials (Basel), 2017
Kreutzburg L, Hübner CG, Paulsen H.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Glyphosate Adsorption on Metal-Organic Framework M₃(BTC)₂: Mechanistic Insights and Descriptors for the Adsorption Energy from Density Functional Calculations. [PDF]

ACS Omega
Putthabal A, Sukhonthachat S, Probst M, Thivasasith A, Limtrakul J, Maihom T.   +5 more
europepmc   +1 more source

Density Functional Calculations for Prediction of ⁵⁷Fe Mössbauer Isomer Shifts and Quadrupole Splittings in β-Diketiminate Complexes. [PDF]

ACS Omega, 2017
McWilliams SF, Brennan-Wydra E, MacLeod KC, Holland PL.   +3 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Selenium Adsorption on the (111), (100), (110) and (211) surfaces of Face-Centered-Cubic Metals: Density Functional Calculations of the Potential Energy Surfaces. [PDF]

ChemistrySelect
Rivera RLA, Colon-Ruiz YL, De La Torre-Rosa A, Garcia-Ramos AI, Garcia-Sanchez AM, Gierbolini-Ortiz L, Lopez-Torres M, Ortiz-Rodriguez N, Rivera-Rivera VA, Santiago-Soler SC, Siberon-Albertorio JA, Silva-Burgos JN, Torres-Morales C, Santana JA.   +13 more
europepmc   +1 more source

Correction to "Density Functional Calculations for Prediction of ⁵⁷Fe Mossbauer Isomer Shifts and Quadrupole Splittings in β-Diketiminate Complexes". [PDF]

ACS Omega, 2017
McWilliams SF, Brennan-Wydra E, MacLeod KC, Holland PL.   +3 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source