Results 81 to 90 of about 9,487,111 (340)

Development of Track Geometrical Evaluation index using Power Spectral Density Method [PDF]

International Journal of Railway Research, 2020
In order to reach a desired quality in railway tracks and to maintain this quality in an acceptable level, a systematic and regular maintenance plan must be performed.
Jabbar Ali Zakeri, Fatemeh Rahmani, roshan talebi   +2 more
doaj  

Imputation of genotypes from low- to high-density genotyping platforms and implications for genomic selection

, 2011
peer-reviewedThe objective of this study was to quantify the accuracy achievable from imputing genotypes from a commercially available low-density marker panel (2730 single nucleotide polymorphisms (SNPs) following edits) to a commercially available ...
J.F. Kearney, Kearney, J.F., D.P. Berry, Berry, Donagh   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Multi-dimensional Morse Index Theorems and a symplectic view of elliptic boundary value problems [PDF]

, 2011
Morse Index Theorems for elliptic boundary value problems in multi-dimensions are proved under various boundary conditions. The theorems work for star-shaped domains and are based on a new idea of measuring the "oscillation" of the trace of the set of ...
Deng, Jian, Jones, C. K. R. T. (Christopher K. R. T.)   +1 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluation of a nutrient-rich food index score in the Netherlands

Journal of Nutritional Science, 2015
Nutrient-rich food (NRF) index scores are dietary quality indices based on nutrient density. We studied the design aspects involved in the development and validation of NRF index scores, using the Dutch consumption data and guidelines as an example.
Diewertje Sluik, Martinette T. Streppel, Linde van Lee, Anouk Geelen, Edith J. M. Feskens   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Nature Genetics, 2018
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels.
A. Mahajan, D. Taliun, Matthias Thurner, N. Robertson, Jason M. Torres, N. W. Rayner, Anthony J. Payne, V. Steinthorsdottir, Robert A. Scott, N. Grarup, J. Cook, Ellen M. Schmidt, M. Wuttke, C. Sarnowski, R. Mägi, J. Nano, C. Gieger, S. Trompet, C. Lecoeur, Michael H. Preuss, Bram P. Prins, Xiuqing Guo, L. Bielak, J. Below, Donald W. Bowden, J. C. Chambers, Y. J. Kim, M. Ng, L. Petty, X. Sim, Weihua Zhang, A. Bennett, J. Bork-Jensen, Chad M. Brummett, M. Canouil, Kai-Uwe Ec kardt, K. Fischer, Sharon L. R. Kardia, F. Kronenberg, Kristi Läll, Ching‐Ti Liu, A. Locke, J. Luan, I. Ntalla, Vibe Nylander, S. Schönherr, C. Schurmann, L. Yengo, Erwin P. Bottinger, I. Brandslund, C. Christensen, G. Dedoussis, J. C. Florez, I. Ford, Oscar H. Franco, T. Frayling, V. Giedraitis, S. Hackinger, A. Hattersley, C. Herder, M. Ikram, M. Ingelsson, Marit E. Jørgensen, T. Jørgensen, J. Kriebel, J. Kuusisto, Symen Ligthart, Cecilia M. Lindgren, A. Linneberg, V. Lyssenko, Vasiliki Mamakou, T. Meitinger, K. Mohlke, Andrew D. Morris, Girish N. Nadkarni, James S. Pankow, A. Peters, N. Sattar, A. Stančáková, K. Strauch, Kent D. Taylor, B. Thorand, G. Thorleifsson, U. Thorsteinsdóttir, J. Tuomilehto, D. R. Witte, J. Dupuis, P. Peyser, E. Zeggini, Ruth J. F. Loos, P. Froguel, E. Ingelsson, L. Lind, L. Groop, M. Laakso, F. Collins, J. Jukema, Colin N. A. Palmer, H. Grallert, A. Metspalu, Abbas Dehghan, A. Köttgen, G. Abecasis, James B. Meigs, J. Rotter, J. Marchini, O. Pedersen, T. Hansen, C. Langenberg, Nicholas J. Wareham, Kári Stefánsson, A. Gloyn, Andrew P. Morris, M. Boehnke, M. McCarthy   +114 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source