Results 141 to 150 of about 5,186,590 (262)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A novel multiscale feature enhancement network using learnable density map for red clustered pepper yield estimation. [PDF]

Front Plant Sci
Cheng C, Lei J, Zhu Z, Lu L, Wang Z, Tao J, Qin X.   +6 more
europepmc   +1 more source

Central New Britain [cartographic material] : provisional map /

, 1943
1st rev. [ed.]. Topographic map of Central New Britain. Relief shown by contours and spot heights.; "This map supercedes previous edition printed in August, 1943."; Includes index to adjoining sheets and reliability diagram.; National Library of ...
United States. Army. South West Pacific Area. Base Map Plant.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A density map-based method for counting wheat ears. [PDF]

Front Plant Sci
Zhang G, Wang Z, Liu B, Gu L, Zhen W, Yao W.   +5 more
europepmc   +1 more source

Is It Conjugated or Not? The Theoretical and Experimental Electron Density Map of Bonding in p-CH₃CH₂COC₆H₄-C≡C-C≡C-p-C₆H₄COCH₃CH₂. [PDF]

Molecules, 2020
Starynowicz P, Berski S, Gulia N, Osowska K, Lis T, Szafert S.   +5 more
europepmc   +1 more source

Western New Britain [cartographic material] : provisional map /

, 1943
1st rev. [ed.]. Topographic map of Western New Britain. Relief shown by contours and spot heights.; "This map supercedes previous edition printed in August 1943."; Includes index to adjoining sheets and reliability diagram.; Also available in an ...
United States. Army. South West Pacific Area. Base Map Plant.
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

CellRegNet: Point Annotation-Based Cell Detection in Histopathological Images via Density Map Regression. [PDF]

Bioengineering (Basel)
Jin X, An H, Chi M.
europepmc   +1 more source

Bismarck Archipelago 1:50,000 [cartographic material] : provisional map /

, 1946
Various editions. Topographic map series of New Britain in the Bismarck Archipelago showing roads, trails, underwater obstructions, intermittent streams, villages, swamps, plantation, mangroves and jungles.
United States. Army. South West Pacific Area. Base Map Plant.
core