Results 101 to 110 of about 543,786 (314)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evaluation of core compositions for use in breed and burn reactors and limited-separations fuel cycles

, 2019
Previously developed methods for analyzing breed-and-burn (B&B) reactors are applied to a wide range of core compositions. The compositions studied include different fuel types, steel and silicon carbide structure, and sodium, lead/lead bismuth eutectic (
Petroski, Robert, Forsberg, Charles, Forget, Benoit   +2 more
core   +1 more source

Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cells

Cellular & Molecular Biology Letters
Background Interfacial heterogeneity is widely explored to reveal molecular mechanisms of force-mediated pathways due to biased tension. However, the influence of cell density,, curvature, and interfacial heterogeneity on underlying pathways of ...
Huayu Fan, Hui Zhao, Yan Hou, Danni Meng, Jizong Jiang, Eon-Bee Lee, Yinzheng Fu, Xiangdong Zhang, Rui Chen, Yongtao Wang   +9 more
doaj   +1 more source

Development Strategy of Continuous Silicon-Carbide-Fiber-Reinforced Silicon Carbide Ceramic Matrix Composites in the Field of Advanced Nuclear Energy

中国工程科学
The development of advanced nuclear energy systems imposes stringent requirements on the service stability of nuclear materials under extreme environments characterized by multiple stressors.
Luo Han , Chen Bowen , Huang Hefei , Wang Canglong , Jiang Zhizhong , Zhou Haishan , Chen Xiangyang , Wang Xiaomin , Zhang Ruiqian , Dong Shaoming   +9 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Chromosome territory position and active relocation in normal and hutchinson-gilford progeria fibroblasts [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Radial chromosome positioning in interphase nuclei is non-random and can alter according to developmental, differentiation, proliferation or disease status.
Mehta, Ishita Shailesh
core  

Optical density of high fluence autoradiographic images to study boron microdistribution: validation of the technique in tissue sections

Frontiers in Nuclear Engineering
The distribution of boron in biological samples coming from BNCT protocols can be determined by the analysis of autoradiographic images formed by nuclear tracks on polymeric detectors.
M. S. Espain, M. S. Espain, M. S. Espain, J. S. Viglietti, C. Vidal, D. Martin, V. A. Trivillin, V. A. Trivillin, A. Monti Hughes, A. Monti Hughes, M. A. Palmieri, L. De Leo, M. A. Garabalino, P. Curotto, S. I. Thorp, E. C. C. Pozzi, G. Saint Martin, A. M. Portu, A. M. Portu, A. M. Portu   +19 more
doaj   +1 more source

A new formula for nuclear level density

Physics Letters B, 1982
Abstract A new formula for the nuclear level density is derived without the use of the saddle-point approximation. The dependence of the level density on the finite dimension of the vector space is explicitly seen. The effect of the neglect of higher moments of the level-density distribution in the saddle-point method is observed at low temperature.
M. Rajasekaran, V. Devanathan
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane

, 2007
Multidrug resistance (MDR) describes the phenomenon whereby cancer cellsexposed to a single cytotoxic drug develop cross resistance to numerous otherstructurally unrelated chemotherapeutics.
Featherstone, Jonathan Mark
core