Results 91 to 100 of about 543,786 (314)

Losses of immunoreactive parvalbumin amacrine and immunoreactive alphaprotein kinase C bipolar cells caused by methylmercury chloride intoxication in the retina of the tropical fish Hoplias malabaricus

Brazilian Journal of Medical and Biological Research, 2006
To quantify the effects of methylmercury (MeHg) on amacrine and on ON-bipolar cells in the retina, experiments were performed in MeHg-exposed groups of adult trahiras (Hoplias malabaricus) at two dose levels (2 and 6 µg/g, ip).
D.M.O. Bonci, S.M.A. de Lima, S.R. Grötzner, C.A. Oliveira Ribeiro, D.E. Hamassaki, D.F. Ventura   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stochastic estimation of nuclear level density in the nuclear shell model: An application to parity-dependent level density in 58 Ni

Physics Letters B, 2016
We introduce a novel method to obtain level densities in large-scale shell-model calculations. Our method is a stochastic estimation of eigenvalue count based on a shifted Krylov-subspace method, which enables us to obtain level densities of huge Hamiltonian matrices.
Shimizu, Noritaka, Utsuno, Yutaka, Futamura, Yasunori, Sakurai, Tetsuya, Mizusaki, Takahiro, Otsuka, Takaharu   +5 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Quantitative Measurements of Breast Density Using Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis [PDF]

, 2019
Breast density, a measure of dense fibroglandular tissue relative to non-dense fatty tissue, is confirmed as an independent risk factor of breast cancer.
Sa dos Reis, Claudia, Sun, Zhonghua, Rooa Sindi, Colleen Bennett, Gil Stevenson, Dos Reis, Claudia Sa, Stevenson, Gil, Cláudia Sá Dos Reis, Zhonghua Sun, Sindi, Rooa, Bennett, Colleen, Stevenson, G., Rooa, Sindi   +12 more
core   +1 more source

FFC NMR Relaxometer with Magnetic Flux Density Control

Journal of Low Power Electronics and Applications, 2019
This paper describes an innovative solution for the power supply of a fast field cycling (FFC) nuclear magnetic resonance (NMR) spectrometer considering its low power consumption, portability and low cost.
António Roque, Duarte M. Sousa, Pedro Sebastião, Elmano Margato, Gil Marques   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Measurements of binding energies and electromagnetic moments of silver isotopes – A complementary benchmark of density functional theory

Physics Letters B
We report on a set of high-precision measurements of nuclear binding and excitation energies, as well as nuclear spins, magnetic dipole and electric quadrupole moments of neutron-rich silver isotopes, 113−123Ag.
R.P. de Groote, D.A. Nesterenko, A. Kankainen, M.L. Bissell, O. Beliuskina, J. Bonnard, P. Campbell, L. Canete, B. Cheal, C. Delafosse, A. de Roubin, C.S. Devlin, J. Dobaczewski, T. Eronen, R.F. Garcia Ruiz, S. Geldhof, W. Gins, M. Hukkanen, P. Imgram, R. Mathieson, Á. Koszorús, I.D. Moore, I. Pohjalainen, M. Reponen, B. van den Borne, M. Vilén, S. Zadvornaya   +26 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Automated Quantification of F-18-Flutemetamol PET Activity for Categorizing Scans as Negative or Positive for Brain Amyloid: Concordance with Visual Image Reads

, 2014
Clinical trials of the PET amyloid imaging agent F-18-flutemetamol have used visual assessment to classify PET scans as negative or positive for brain amyloid.
Lilja, J., Vandenberghe, R., Thurfjell, Lennart,, Buckley, C., Smith, A., Sherwin, P., Lundqvist, R.   +6 more
core   +1 more source