Results 71 to 80 of about 543,786 (314)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Level studies of 93Mo via 93Nb(p, nγ)93Mo reaction and density of discrete levels in 93Mo
, 2011 The excited states of 93Mo have been investigated via the 93Nb(P,nγ)93Mo reaction with proton beam energies of 2.5-4.3 MeV. The parameters of the nuclear level density formula were determined from the extensive and complete level scheme of 93Mo.
Razavi Rohallah, Kakavand Tayeb
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Metals, 2020 Safe and long term operation of nuclear reactors is one of the most discussed challenges in nuclear power engineering. The radiation degradation of nuclear design materials limits the operational lifetime of all nuclear installations or at least ...
Vladimír Slugeň +5 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
The morphology of single PWR UO2 fuel rods has been investigated by employing computerised gamma-ray transmission tomography. Four highly burnt fuel rods of different burnups (from 52 GWd/t to 126GWd/t) and a fresh rod have been investigated.
Chawla, Rakesh +3 more
core +1 more source
Large-Scale Candidate Gene Analysis of HDL Particle Features
, 2011 Background: HDL cholesterol (HDL-C) is an established marker of cardiovascular risk with significant genetic determination. However, HDL particles are not homogenous, and refined HDL phenotyping may improve insight into regulation of HDL metabolism.
Burton Paul R. +125 more
core +1 more source
Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition [PDF]
, 2012 Meiosis is the cell division that halves the genetic component of diploid cells to form gametes or spores. To achieve this, meiotic cells undergo a radical spatial reorganisation of chromosomes.
Penfold, Christopher A. +19 more
core +1 more source
Decreased DNA density is a better indicator of a nuclear bleb than lamin B loss.
Nuclear blebs are herniations of the nucleus that occur in diseased nuclei and cause nuclear rupture leading to cellular dysfunction. Chromatin and lamins are two of the major structural components of the nucleus that maintain its shape and function, but
core +3 more sources