Results 71 to 80 of about 1,135,168 (297)

Path integral formulation for quantum nonadiabatic dynamics and the mixed quantum-classical limit [PDF]

, 2007
This work identifies geometric effects on dynamics due to nonadiabatic couplings in Born Oppenheimer systems and provides a systematic method for deriving corrections to mixed quantum-classical methods. Specifically, an exact path integral formulation of
Krishna, Vinod
core   +2 more sources

Constant temperature description of the nuclear level densities [PDF]

AIP Conference Proceedings, 2017
The spin and parity dependent nuclear level densities (NLD) are calculated for medium-heavy nuclei using shell model techniques. The NLD are used to calculate cross sections and reaction rates of interest for nuclear astrophysics and nuclear energy applications.
Horoi, Mihai, Dissanayake, Jayani
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Dihydromyricetin promotes LDL metabolism in HepG2 cells through the PCSK9/LDLR pathway

CyTA - Journal of Food, 2023
Low-density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) play a pivotal role by regulating plasma low-density lipoprotein cholesterol (LDL-c) levels.
Li-Tian Wang, Dan-Dan Hu, Hua-Rong Liu, Huai-Liu Yin, Rui Mu, Yu-Hang Yang, Run-Yu Zhao, Jun Sheng, Ye-Wei Huang, Xuan-Jun Wang   +9 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

Scientific Reports, 2021
Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE).
Anna Kychygina, Marina Dall’Osto, Joshua A. M. Allen, Jean-Charles Cadoret, Vincent Piras, Hilda A. Pickett, Laure Crabbe   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Combinatorial study of nuclear level density for astrophysical applications [PDF]

Nuclear Physics A, 1994
We present some results and remarks based on a combinatorial approach of the evaluation of the nuclear level density. First, we show that it is possible to extract some reliable information from the output of the program whose rough data present a strong statistical fluctuation from bin to bin.
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Removing uncertainties from X-ray Busrt Models [PDF]

EPJ Web of Conferences
Two of the astrophysically important reactions for X-ray burst models are 24Mg(α, γ)28Si and 59Cu(p, γ)60Zn. However, since these models are sensitive to nuclear reaction rates, it is important to constrain them to reduce possible model uncertainties ...
Singh Nisha, Brune Carl, Voinov Alexander   +2 more
doaj   +1 more source