Results 51 to 60 of about 543,786 (314)

Chromatin organization drives the search mechanism of nuclear factors

Nature Communications, 2023
Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell single-molecule tracking with multifocal structured ...
Matteo Mazzocca, Alessia Loffreda, Emanuele Colombo, Tom Fillot, Daniela Gnani, Paola Falletta, Emanuele Monteleone, Serena Capozi, Edouard Bertrand, Gaelle Legube, Zeno Lavagnino, Carlo Tacchetti, Davide Mazza   +12 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells.

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
core   +1 more source

Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression [PDF]

, 2007
Copyright @ 2007 The Rockefeller UniversityRadial organization of nuclei with peripheral gene-poor chromosomes and central gene-rich chromosomes is common and could depend on the nuclear boundary as a scaffold or position marker. To test this, we studied
Vaux, DJ, David J. Vaux, Lee, Chiu, Lee, CF, Rebecca Sanders, Malhas, A, Ashraf Malhas, Chiu Fan Lee, Saunders, Nigel, Saunders, NJ, Sanders, R, Nigel J. Saunders   +11 more
core   +1 more source

Neutron induced fission cross section calculation for tungsten, tantalum, bismuth and lead nuclei using CEM03.03 and TALYS

Cumhuriyet Science Journal
[1]I. A. E. AGENCY, Climate Change and Nuclear Power 2020, Climate Change and Nuclear Power 2020 1 (2020).[2]M. D. Mathew, Nuclear Energy: A Pathway towards Mitigation of Global Warming, Progress in Nuclear Energy.[3]N.
Murat Dağ
doaj   +1 more source

Nuclear Level Densities

EPJ Web of Conferences
Nuclear reaction models, and in particular compound nucleus reactions, require the knowledge of nuclear level densities (NLDs), among other ingredients. For decades, analytical expressions have been used in nuclear reaction codes, due to the freedom they offer to the user to modify their associated parameters in order to fit cross sections.
Hilaire, Stéphane, Goriely, Stéphane, Péru, Sophie   +2 more
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Erl, Wolfgang, Weber, Christian, Kim S. C. Weber, Weber, Kim S.C., Weber, Peter C., Wolfgang Erl, Peter C. Weber, Christian Weber   +7 more
core   +1 more source

Histomorphometric Evaluation of Myocardial Tissue Zones in Patients With Persistent Hypokalemia

Pakistan Journal of Medicine and Dentistry
Background: Persistent hypokalemia influences cardiac structure and function, but its zonal effect on myocardial remodeling is not definite. This study quantitatively examined myocardial tissue zones in chronic hypokalemia, to build a schematic model of
Iqra, Amber, Pashmina Shaikh, Sumair Akbar Ali Memon, Masroor Hassan, Khalida Akram, Amanullah Khan   +6 more
doaj   +1 more source

Dataset of observables for UOX and MOX spent fuel extracted from Serpent2 fuel depletion calculations for PWRs

Data in Brief, 2023
This database contains the isotopic mass density and the contribution to activity, decay heat, photon emission, spontaneous fission rate, (α,n) emission rates and radiotoxicity of 150 nuclides that are present in nuclear fuel irradiated in PWRs.
Victor J. Casas-Molina, Augusto Hernandez-Solis, Pablo Romojaro, Ivan Merino-Rodríguez, Nerea Aguilera-Gómez   +4 more
doaj   +1 more source