Results 41 to 50 of about 543,786 (314)

Role of Ultrasonographic and Clinicopathological Characteristics in Assessing Stromal Tumor-Infiltrating Lymphocyte Density in Triple-Negative Breast Cancer

Balkan Medical Journal
Background: A high density of stromal tumor-infiltrating lymphocytes (sTILs) is positively correlated with the pathological complete response rate and favorable survival in patients with triple-negative breast cancer (TNBC).
Lian Li, Yingjia Li
doaj   +1 more source

Nuclear level densities in the constant-spacing model [PDF]

Physics Letters B, 2013
A new method to calculate level densities for non-interacting Fermions within the constant-spacing model with a finite number of states is developed. We show that asymptotically (for large numbers of particles or holes) the densities have Gaussian form.
Pálffy, A., Weidenmüller, H.
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

3,5,3’-triiodo-L-thyronine- and 3,5-diiodo-L-thyronine- affected metabolic pathways in liver of LDL receptor deficient mice

Frontiers in Physiology, 2016
3,5,3’-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2), when administered to a model of familial hypercholesterolemia, i.e. low density lipoprotein receptor (LDLr)-knockout (Ldlr-/-) mice fed with a Western type diet (WTD), dramatically reduce ...
Maria Moreno, Elena Silvestri, Maria Coppola, Ira J. Goldberg, Li-Shin Huang, Anna Maria Salzano, Fulvio D’Angelo, Joel R. Ehrenkranz, Fernando Goglia   +8 more
doaj   +1 more source

On the angular-momentum dependence of nuclear-level densities [PDF]

Nuclear Physics A, 1994
19 Latex pages, 9 figures(available upon request)
Agrawal, B. K., Ansari, A.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Targeted deficiency of the transcriptional activator Hnf1 alpha alters subnuclear positioning of its genomic targets [PDF]

, 2008
DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails.
Luco, Reini F., Sadoni, Nicolas, Maestro, Miguel A., Miguel A Maestro, Luco Reini F., Ferrer Jorge, Zink Daniele, Daniele Zink, Sadoni Nicolas, Nicolas Sadoni, Jorge Ferrer, Maestro Miguel A., Ferrer, Jorge, Reini F Luco, Zink, Daniele   +14 more
core   +1 more source

Predicting Nuclear Level Density Using a Physics-Informed Neural Network with Multi-Task Learning

Applied Sciences
The accurate determination of nuclear level density (NLD) is essential for a wide range of applications in nuclear science, including reactor design, nuclear astrophysics, and nuclear data evaluation.
Bora Canbula
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar, Jaroslaw Paturej, Edward J. Banigan, Aykut Erbaş   +3 more
doaj   +1 more source