Results 61 to 70 of about 764,835 (270)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Functional diversity of microbial ecologies estimated from ancient human coprolites and dental calculus

Philosophical Transactions of the Royal Society of London. Biological Sciences, 2020
Human microbiome studies are increasingly incorporating macroecological approaches, such as community assembly, network analysis and functional redundancy to more fully characterize the microbiome.
David K. Jacobson, Tanvi P. Honap, C. Monroe, Justin R. Lund, Brett A. Houk, Anna C. Novotny, Cynthia Robin, E. Marini, Cecil M. Lewis   +8 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Periodontal status among 12-year-old schoolchildren: a population-based cross-sectional study in Quito, Ecuador

Brazilian Oral Research
This study aimed to estimate the prevalence and extent of bleeding on probing and calculus in 12-year-old schoolchildren of Quito, Ecuador, and evaluate the associated factors.
Marco MEDINA-VEGA, Mariela Cumandá Balseca IBARRA, Maritza Del Carmen QUEZADA-CONDE, Isabella Neme Ribeiro dos REIS, Antonio Carlos FRIAS, Daniela Prócida RAGGIO, Edgard MICHEL-CROSATO, Fausto Medeiros MENDES, Claudio Mendes PANNUTI, Giuseppe Alexandre ROMITO   +9 more
doaj   +1 more source

Investigating Plant Micro-Remains Embedded in Dental Calculus of the Phoenician Inhabitants of Motya (Sicily, Italy)

Plants, 2020
Plant records reveal remarkable evidence about past environments and human cultures. Exploiting dental calculus analysis and using a combined approach of microscopy and gas chromatography mass spectrometry, our research outlines dietary ecology and ...
A. D’Agostino, A. Canini, G. Di Marco, L. Nigro, F. Spagnoli, A. Gismondi   +5 more
semanticscholar   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Assessment of Dental Calculus, Plaque and GingivalInflammation in Patients with Urinary Stone

Journal of Baghdad College of Dentistry, 2019
Background: Dental calculus is mineralized dental plaque formed on teeth and dental prosthesis surfaces in the oral cavity. Urinary stone is a crystal aggregation formed in urinary system due to minerals saturation present in urine.
Maher B Mohammed, Maha Sh. Mahmood
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Medieval women’s early involvement in manuscript production suggested by lapis lazuli identification in dental calculus

Science Advances, 2019
Lapis lazuli preserved in plaque reveals that medieval women were actively involved in producing richly illustrated manuscripts. During the European Middle Ages, the opening of long-distance Asian trade routes introduced exotic goods, including ...
Anita Radini, Anita Radini, Monica Tromp, Monica Tromp, Alison I. Beach, Emma Tong, Camilla Speller, Camilla Speller, Michael McCormick, John V. Dudgeon, Matthew J. Collins, Matthew J. Collins, F. Rühli, Roland Kröger, Christina Warinner, Christina Warinner, Christina Warinner   +16 more
semanticscholar   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source