Results 81 to 90 of about 85,772,716 (308)

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Use of dental care services among adolescents living with HIV on antiretroviral treatment in Kampala, Uganda: a cross-sectional study

BMC Oral Health
Objective The primary purpose of this study was to assess the prevalence and socio-behavioral determinants of ever-use of dental care services among adolescents aged 10–18 years, living with HIV, on Antiretroviral treatment (ART), and attending selected ...
Maria Gorretti Nakyonyi, Nancy Birungi, Catherine Lutalo Mwesigwa, Anne Nordrehaug Åstrøm   +3 more
doaj   +1 more source

Determining the optimal model for role-substitution in NHS dental services in the United Kingdom [PDF]

, 2013
Background: Role-substitution describes a model of dental care where Dental Care Professionals (DCPs) provide some of the clinical activity previously undertaken by General Dental Practitioners.
Tickle, Martin, Stephen Birch, Paul Brocklehurst, Birch, Stephen, McDonald, Ruth, Martin Tickle, McDonald, R, Brocklehurst, Paul, Brocklehurst, P, Tickle, M, Birch, S; id_orcid, Ruth McDonald   +11 more
core   +2 more sources

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Efficacy of an oral hygiene intervention on a geriatric ward: from sample size calculation to dropout-driven disillusionment - a randomised controlled study

BMC Oral Health
Background Older home-dwelling adults with care needs often demonstrate deficient oral hygiene due to cognitive and motor impairments, as evidenced by increased plaque levels, which can compromise oral and general health.
Nora Marie Eckhardt, Max von Kohout, Dirk Bleiel, M. Cristina Polidori, Anna Greta Barbe   +4 more
doaj   +1 more source

Tooth agenesis in patients referred to an Irish tertiary care clinic for the developmental dental disorders. [PDF]

, 2010
This study was carried out to determine the prevalence, severity and pattern of hypodontia in Irish patients referred to a tertiary care clinic for developmental dental disorders ...
Garvey, Therese, O'Connell, Anne, O'Connell, Brian, O'Sullivan, Michael, Nunn, June, Hashem, Atef A   +5 more
core  

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Is private insurance enough to address barriers to accessing dental care? Findings from a Canadian population-based study

BMC Oral Health
Background In Canada, as in many other countries, private dental insurance addresses financial barriers to a great extent thereby facilitating access to dental care.
Mona Abdelrehim, Sonica Singhal
doaj   +1 more source

Depression in residential aged care 2008-2012 [PDF]

, 2013
Entry into residential aged care can be challenging, with its changes to routine, loss of independence and physical relocation to a new environment. The presence of depression adds to this. Depression is a serious but manageable condition that can affect

core