Results 181 to 190 of about 316,514 (314)

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Development of a core curriculum framework in cariology for U.S. dental schools

, 2016
Maintenance of health and preservation of tooth structure through risk-based prevention and patient-centered, evidencebased disease management, reassessed at regular intervals over time, are the cornerstones of present-day caries management.
Pitts, Nigel Berry, Allen, Kenneth L., Fontana, Margherita, Martignon, Stefania, Schenkel, Andrew B., Goolsby, Susie P., Schulte, Andreas Gerhard, Kanjirath, Preetha P., Guzmán-Armstrong, Sandra, Young, Douglas A., Kolker, Justine L., Slayton, Rebecca L., Featherstone, John DB   +12 more
core  

The association between maternal smoking during pregnancy and dental development in offspring: a systematic review. [PDF]

Evid Based Dent
Tiernan H, Masud M, Lange S, Nanayakkara S, Jayasinghe TN.   +4 more
europepmc   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source

Membrana preformativa: Unveiling the unexplored facets of dental development. [PDF]

J Oral Biol Craniofac Res
Sikaria S, Selvam SP, Ramadoss R, Sundar S.   +3 more
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Longitudinal Study on the Impact of Orthodontic Treatment Timing on Skeletal and Dental Development in Adolescents. [PDF]

J Pharm Bioallied Sci
Adarsh K, Goyal JD, Kaur GP, Neeharika T, Samal S, Datla PKV, Ravuri P.   +6 more
europepmc   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Association of PTH and vitamin D-related genes with dental development in Brazilian children: a cross-sectional study. [PDF]

Braz Oral Res
Madalena IR, Küchler EC, Reis CLB, Matsumoto MAN, Stuani MBS, Vilalba Paniagua Machado do Nascimento T, Kirschneck C, Baratto-Filho F, Menezes-Oliveira MAH, Lepri CP.   +9 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source