The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Incidence and impact of odontogenic infection-related febrile episodes during perioperative doxorubicin-cyclophosphamide or docetaxel-cyclophosphamide chemotherapy for breast cancer. [PDF]
Soga Y +10 more
europepmc +1 more source
Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen +23 more
wiley +1 more source
Subdural empyema in a 14-year-old female initially diagnosed as meningitis: a case report of a rare <i>Streptococcus constellatus</i> infection. [PDF]
Abu Thiab M +3 more
europepmc +1 more source
Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar +18 more
wiley +1 more source
Oral Motion-Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect. [PDF]
Shi X +15 more
europepmc +1 more source
Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal +2 more
wiley +1 more source
Burrata and the Bean: A Rare Case of <i>Lactobacillus casei</i> Endocarditis Complicated by Rapidly Progressive Glomerulonephritis. [PDF]
Chavez J +3 more
europepmc +1 more source
ABSTRACT Purpose/Objectives Insufficient tooth reduction compromises crown longevity and aesthetics. This study aimed to determine whether digitally designed, 3D‐printed reduction guides improved crown preparation accuracy and efficiency for dental students compared to freehand preparation.
Xiaoyue Shi, Shuncong Xu, Chenxuan Wei
wiley +1 more source
Research Progress and Translational Perspectives of Piezoelectric Materials in Dental Implant Surface Engineering. [PDF]
Cao X +5 more
europepmc +1 more source

