Results 221 to 230 of about 2,476,351 (296)

Human biomarker navigator

open access: yesiMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li   +29 more
wiley   +1 more source

Incidence and impact of odontogenic infection-related febrile episodes during perioperative doxorubicin-cyclophosphamide or docetaxel-cyclophosphamide chemotherapy for breast cancer. [PDF]

open access: yesSupport Care Cancer
Soga Y   +10 more
europepmc   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

open access: yesiMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen   +23 more
wiley   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

open access: yesInterdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar   +18 more
wiley   +1 more source

Oral Motion-Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect. [PDF]

open access: yesAdv Sci (Weinh)
Shi X   +15 more
europepmc   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal   +2 more
wiley   +1 more source

Comparing Digital Reduction Guides and Free‐Hand Techniques for Predoctoral Crown Preparation Accuracy

open access: yesJournal of Dental Education, EarlyView.
ABSTRACT Purpose/Objectives Insufficient tooth reduction compromises crown longevity and aesthetics. This study aimed to determine whether digitally designed, 3D‐printed reduction guides improved crown preparation accuracy and efficiency for dental students compared to freehand preparation.
Xiaoyue Shi, Shuncong Xu, Chenxuan Wei
wiley   +1 more source

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