Results 1 to 10 of about 215,136 (185)

Zebrafish Larvae as an in vivo Model for Antimicrobial Activity Tests against Intracellular Salmonella

Frontiers in Bioscience-Landmark, 2023
Introduction: Blood infections from multi-drug-resistant Salmonella pose a major health burden. This is especially true because Salmonella can survive and replicate intracellularly, and the development of new treatment strategies is dependent on ...
Patrick Hauswirth, Jonas Buck, Ramya Puligilla, Claudio Luca Alter, Sandro Sieber, Beatrice Claudi, Joseph Fanous, Dirk Bumann, Jörg Huwyler   +8 more
doaj   +1 more source

Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis

Frontiers in Immunology, 2020
Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro ...
Mauricio Rosas-Ballina, Xue Li Guan, Alexander Schmidt, Dirk Bumann   +3 more
doaj   +1 more source

A Single-Domain Response Regulator Functions as an Integrating Hub To Coordinate General Stress Response and Development in Alphaproteobacteria

mBio, 2018
The alphaproteobacterial general stress response is governed by a conserved partner-switching mechanism that is triggered by phosphorylation of the response regulator PhyR.
C. Lori, A. Kaczmarczyk, I. de Jong, U. Jenal   +3 more
doaj   +1 more source

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape

Nature Communications, 2017
The pathogenicity ofFrancisellaspecies largely depends on their escape from phagosomes in macrophages, mediated by a type VI secretion system (T6SS). Here, the authors show dynamics of T6SS assembly and disassembly and identify the genes essential for ...
Maj Brodmann, Roland F. Dreier, Petr Broz, Marek Basler   +3 more
doaj   +1 more source

Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein

mBio, 2017
When encountering surfaces, many bacteria produce adhesins to facilitate their initial attachment and to irreversibly glue themselves to the solid substrate.
Kathrin S. Sprecher, Isabelle Hug, Jutta Nesper, Eva Potthoff, Mohamed-Ali Mahi, Matteo Sangermani, Volkhard Kaever, Torsten Schwede, Julia Vorholt, Urs Jenal   +9 more
doaj   +1 more source

The type VI secretion system sheath assembles at the end distal from the membrane anchor

Nature Communications, 2017
The bacterial Type VI secretion system (T6SS) delivers proteins into target cells using fast contraction of a long sheath anchored to the cell envelope. Here, Vettigeret al.
Andrea Vettiger, Julius Winter, Lin Lin, Marek Basler   +3 more
doaj   +1 more source

The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer

Cell Reports, 2017
Bacteria use type VI secretion systems (T6SSs) to manipulate host cells during pathogenesis or to kill competing bacteria, which, in some cases, increases horizontal gene transfer.
Peter David Ringel, Di Hu, Marek Basler
doaj   +1 more source

Evaluation of telemedicine in the management of dentogenous infections [PDF]

Vojnosanitetski Pregled, 2013
Introduction/Aim. The first written evidence of telemedicine dates back to the times of Sava Nemanjić (the end of 12th and the beginning of 13th century).
Miladinović Milan, Mladenović Dragan, Mihailović Branko, Tošić Goran, Đinđić Boris, Mladenović Sanja, Hadžibeti Mervan, Vujičić Biljana   +7 more
doaj   +1 more source

ASC filament formation serves as a signal amplification mechanism for inflammasomes

Nature Communications, 2016
Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome ...
Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller, Petr Broz   +4 more
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

Cell Reports, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Alexander Harms, Frédéric Valentin Stanger, Patrick Daniel Scheu, Imke Greet de Jong, Arnaud Goepfert, Timo Glatter, Kenn Gerdes, Tilman Schirmer, Christoph Dehio   +8 more
doaj   +1 more source