Results 41 to 50 of about 215,255 (304)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Scientific Reports, 2023
We looked for predicting factors for the detection of infectious foci on 18F-fluorodeoxyglucose-positron emission tomography in combination with computed tomography (FDG PET/CT) among patients with Staphylococcus aureus bacteremia (SAB) who participated ...
Nesrin Ghanem-Zoubi, Jawad Abu-Elhija, Olga Kagna, Mona Mustafa-Hellou, Majd Qasum, Daniel Haber, Mical Paul, Zohar Keidar   +7 more
doaj   +1 more source

FOCAL INFECTION [PDF]

Journal of the American Medical Association, 1914
Circumscribed and confined infection, commonly expressed as focal infection, has long been recognized as an important etiologic factor in systemic disease. Yet as a principle it has not received sufficient attention from practitioners. In my opinion focal infection is very frequently related to local and general disease.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Extra-Palmoplantar Lesions of Palmoplantar Pustulosis: Underrecognized but Important Manifestation

Indian Journal of Dermatology
Background: Patients with palmoplantar pustulosis (PPP) rarely develop scaly erythematous and/or pustular lesions on sites other than the palms and soles, such as the dorsa of the feet, lower legs, knees, elbows, buttocks and trunk.
Toshiyuki Yamamoto
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Plasma ddPCR for etiological diagnosis of focal bacterial infections

Frontiers in Medicine
BackgroundPlasma droplet digital polymerase chain reaction (ddPCR) has been used for pathogen detection and has shown good diagnostic value, but no studies have yet demonstrated its application in focal infections. Herein a pilot study using plasma ddPCR
Yongfeng Zhang, ShanShan Weng, ShanShan Weng, ShanShan Weng, Xueqing Ma, Xueqing Ma, Xueqing Ma, Ling Lin, Ling Lin, Ling Lin, Ling Lin, Yueliang Chen, Binbin Feng, Jiang Xia, Jiayuan Ye, Hua Zhou, Yunsong Yu, Yunsong Yu, Yunsong Yu, Dongdong Zhao, Dongdong Zhao, Dongdong Zhao, Dongdong Zhao   +22 more
doaj   +1 more source

Estado actual de la infección focal y del éxito del tratamiento endodóntico //Current status of focal infection and the success of endodontic treatment

Revista de la Asociación Odontológica Argentina, 2023
Resumen Frente a la difusión en medios de comunicación de medias verdades con enunciados alarmantes y anticientíficos, este editorial busca revisar las bases científicas para determinar el comportamiento clínico.
Manoel Machado
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source