Results 1 to 10 of about 1,766,565 (120)

Thrombosis and Hyperinflammation in COVID-19 Acute Phase Are Related to Anti-Phosphatidylserine and Anti-Phosphatidylinositol Antibody Positivity

Biomedicines, 2023
Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities.
Jaume Alijotas-Reig, Ariadna Anunciación-Llunell, Stephanie Morales-Pérez, Jaume Trapé, Enrique Esteve-Valverde, Francesc Miro-Mur   +5 more
doaj   +1 more source

Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial

Trials, 2022
Background Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity.
Mieke van Schaik, Eline J. Arends, Darius Soonawala, Ellen van Ommen, Karina de Leeuw, Maarten Limper, Pieter van Paassen, Tom W. J. Huizinga, René E. M. Toes, Cees van Kooten, Joris I. Rotmans, Ton J. Rabelink, Y. K. Onno Teng   +12 more
doaj   +1 more source

Gynecological Fistulae—Has Anything Changed in the Diagnosis and Treatment over the Last Decade? A Narrative Literature Review

Medicina, 2023
Gynecological fistulae are a rare but severe complication of radiation therapy, pelvic surgery, prolonged labor, cesarean deliveries, or inflammatory bowel diseases.
Marek Misiak, Michalina Dworak, Małgorzata Wyszomirska, Maria Kurt, Maciej Walędziak, Anna Różańska-Walędziak   +5 more
doaj   +1 more source

Synchrotron radiation analysis of root dentin: the roles of fluoride and calcium ions in hydroxyapatite remineralization

Journal of Synchrotron Radiation, 2022
Although the use of fluoride for root caries control is reported to be effective, the mechanism of maintaining hydroxyapatite is still unclear. This study elucidates the roles of fluoride in the recrystallization of hydroxyapatite, and the impact of ...
Nutthapong Kantrong, Krassawan Khongkhaphet, Nutnicha Sitornsud, Pakaporn Lo-apirukkul, Waraporn Phanprom, Catleya Rojviriya, Penphitcha Amonpattaratkit, Watcharaphong Ariyakriangkai   +7 more
doaj   +1 more source

Research progress on salivary exosomes and oral diseases

口腔疾病防治, 2022
Salivary exosomes are extracellular vesicles with a diameter of 30-50 nm in saliva. With the development of technology in recent years, many studies have revealed that salivary exosomes play an important role in the occurrence and development of various ...
SUN Yan, CHENG Lei, PENG Xian
doaj   +1 more source

Long-Term Outcomes of Behçet’s Syndrome-Related Uveitis: A Monocentric Italian Experience

Mediators of Inflammation, 2020
Objectives. To examine demographic and clinical characteristics and long-term visual outcome in a cohort of Italian patients affected by Behçet’s uveitis (BU). Materials and Methods.
Jurgen Sota, Luca Cantarini, Antonio Vitale, Arianna Sgheri, Stefano Gentileschi, Valeria Caggiano, Viviana Gelardi, Bruno Frediani, Gian Marco Tosi, Claudia Fabiani   +9 more
doaj   +1 more source

Real-Life Data on the Efficacy of Canakinumab in Patients with Adult-Onset Still’s Disease

Mediators of Inflammation, 2020
Background. Interleukin-1 inhibition has revealed to be a successful treatment approach for patients with adult-onset Still’s disease (AOSD). However, real-life experience is focused on the use of anakinra, while data about canakinumab (CAN) are mainly ...
Antonio Vitale, Virginia Berlengiero, Jurgen Sota, Luisa Ciarcia, Nicola Ricco, Sara Barneschi, Mariam Mourabi, Giuseppe Lopalco, Chiara Marzo, Francesca Bellisai, Florenzo Iannone, Bruno Frediani, Luca Cantarini   +12 more
doaj   +1 more source

Periodontitis may predict the use of prescription medicines later in life, a database study

Frontiers in Pharmacology, 2023
Medications used for the treatment of diseases also affect oral health. We investigated how having/not having periodontitis at baseline in 1985 was associated with purchases of medicines in the long term. The study paradigm is in the oral health-systemic
Freja Frankenhaeuser, Birgitta Söder, Håkan Källmén, Esa R. Korpi, Jukka H. Meurman   +4 more
doaj   +1 more source

Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells

Tobacco Induced Diseases, 2012
Background The primary, stable metabolite of nicotine [(S)-3-(1-methyl-2-pyrrolidinyl) pyridine] in humans is cotinine [(S)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone].
Juhi Bagaitkar, Iris Zeller, Diane E Renaud, David A Scott   +3 more
doaj   +1 more source

Research progress on the mechanism of C-reactive protein mediated periodontitis and systemic diseases

口腔疾病防治, 2020
A large number of studies have confirmed that periodontitis is closely related to systemic multisystem diseases. Local inflammation of periodontal tissue may cause systemic inflammation.
ZHANG Limu, LIN Xiaoping
doaj   +1 more source