Results 21 to 30 of about 7,269,468 (262)
Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [PDF]
, 2011 Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis ...
P. Amouyel +245 more
core +2 more sources
Long term impact of systemic bacterial infection on the cerebral vasculature and microglia [PDF]
, 2012 Background: Systemic infection leads to generation of inflammatory mediators that result in metabolic and behavioural changes. Repeated or chronic systemic inflammation leads to a state of innate immune tolerance: a protective mechanism against over ...
Perry, V. Hugh +11 more
core +3 more sources
Autoantibodies against complement C1q in systemic lupus erythemathosus [PDF]
, 2008 Complement and C1q, the first component of the classical pathway of activation of the complement system, are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), a systemic autoimmune disease.
Bigler, Cornelia
core +1 more source
Hints for Genetic and Clinical Differentiation of Adult-Onset Monogenic Autoinflammatory Diseases
Mediators of Inflammation, 2019 Monogenic autoinflammatory diseases (mAIDs) are inherited errors of innate immunity characterized by systemic inflammation recurring with variable frequency and involving the skin, serosal membranes, synovial membranes, joints, the gastrointestinal tube,
Carla Gaggiano +11 more
doaj +1 more source
Osteoarthritis as an organ disease: from the cradle to the grave [PDF]
European Cells & Materials, 2019 Considered for decades as a cartilage disease, recent studies of osteoarthritis (OA) take us back to the concepts discussed at the naming of the disorder as “bone-joint-inflammation”. By describing the joint as an organ, can OA be called an organ disease
RM Aspden, FR Saunders
doaj +1 more source
Comorbidities in COPD patients [PDF]
Batna Journal of Medical Sciences, 2023 Background. Chronic obstructive pulmonary disease (COPD) is associated with several comorbidities, it is considered actually as a systemic disease.
Rachida Djebaili, Boutheina Chiboub
doaj +1 more source
Systemic Disease in Patients with Obstructive Sleep Apnea Syndrome [PDF]
, 2015 Objective In this study, we investigated 304 patients diagnosed with Obstructive sleep apnea syndrome (OSAS) and undergoing standard polysomnography in our sleep laboratory between December, 2013 and January 2015 in terms of anamnesis, drugs used and ...
Adem Yılmaz, Aydın Çiledağ
core +1 more source
Lupus Science and MedicineObjective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking.
Tineke Kraaij +11 more
doaj +1 more source
TMJ Dysfunction and Systemic Correlation
Journal of Functional Morphology and Kinesiology, 2020 In recent years it has been conclusively shown how the position of the mouth in relation to the body affects the way of walking and standing. In particular, occlusion, the relationship between skull and jaw, swallowing and convergence of the eyes are in ...
Luca Fiorillo, Giuseppe Musumeci
doaj +1 more source
Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection
Gut Microbes, 2022 Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea, with disease mediated by two major toxins TcdA and TcdB. In severe cases, systemic disease complications may arise, resulting in fatal disease.
Steven J. Mileto +9 more
doaj +1 more source