Results 61 to 70 of about 90,284 (314)

Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains [PDF]

, 2014
Periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial components, which may contribute to the development of Alzheimer’s disease.
Chukkapalli, Sasanka, Crean, Stjohn, Kesavalu, Lakshmyya, Poole, Sophie, Rivera, Mercedes, Singhrao, Simarjit Kaur, Velsko, Irina   +6 more
core   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC:is there evidence to support a prognostic or diagnostic role? [PDF]

, 2014
BACKGROUND: Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk.
Cochrane, Lynda, Ellis, Ian R., Islam, Mohammad R., Jones, Sarah J., Macluskey, Michaelina   +4 more
core   +3 more sources

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Comparison of osseointegration in piezoimplants versus cylindrical implants [PDF]

, 2019
BACKGROUND: Dental implants have been successful for the restoration of edentulous areas, but current techniques are inadequate in areas lacking sufficient bone volume. Piezoelectric surgery has shown encouraging effects on both osseous healing.
Fujinaka, Trevor
core  

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection. [PDF]

, 2013
A majority of individuals infected with human immunodeficiency virus (HIV) have inadequate access to antiretroviral therapy and ultimately develop debilitating oral infections that often correlate with disease progression.
A Uehara, Aftab A. Ansari, Angeline T. Dang, AR Thurman, AT Dang, BA Dale, BL Shacklett, BP Gomes, Bruce J. Paster, C Beaurepaire, C Gervasoni, C Heise, Chin-Shang Li, Christina Murphy, D Preza, DA Reznik, DR Dixon, E Elinav, E Zaura, F Meurens, FE Dewhirst, G Diamond, G Diamond, G Xie, H Wang, H Yang, HT Rupniak, I Viard-Leveugle, J Benes, J Mitchell, JA Aas, JA Aas, JC Leao, JE Hull, JE Meyer, JM Garcia-Lechuz, JT Arotiba, L Feller, M Bando, M Bruewer, M Guadalupe, M Mittal, M Raffatellu, MD George, MD George, MD George, MH Shaw, Michael D. George, MP George, MT Pollanen, Niku Borujerdpur, P Regenhard, R Saini, RM Zakir, Ross Tarara, RS Veazey, S Chotai, S Gennaro, S Sugawara, Satya Dandekar, Sumathi Sankaran-Walters, Susan Ocon, T Chen, TG Shrihari, W Hartzell, Z Smit-McBride   +65 more
core   +3 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Endodontic treatment in geriatric patients

Padjadjaran Journal of Dentistry, 2007
With the increased number of geriatric population, it is predicted that the need for dental treatment also increases. The needs for esthetic factors and function of geriatric patient are maybe similar to young patient.
Milly Armilya Andang, Kurniasri Amas Achiar   +1 more
doaj   +1 more source

Nanoroughness, Surface Chemistry and Drug Delivery Control by Atmospheric Plasma Jet on Implantable Devices [PDF]

, 2018
Implantable devices need specific tailored surface morphologies and chemistries to interact with the living systems or to actively induce a biological response also by the release of drugs or proteins.
Ambrosi, Emmanuele, Brun, Paola, Genova, Tullio, Mattei, Giovanni, Michieli, Niccol\uf2 T, Moroni, Lorenzo, Mussano, Federico, Patelli, Alessandro, Scopece, Paolo   +8 more
core   +3 more sources