Results 211 to 220 of about 1,654,035 (409)

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

open access: yesAdvanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan   +12 more
wiley   +1 more source

The Influence of First-Stage Mobility on the Osseointegration of Dental Implants

open access: hybrid, 1994
Frank R. Lauciello   +7 more
openalex   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu   +10 more
wiley   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo   +20 more
wiley   +1 more source

Dental patients’ awareness and knowledge in using dental implants as an option in replacing missing teeth: A survey in Riyadh, Saudi Arabia

open access: yesSaudi Dental Journal, 2010
Aim: The purpose of this survey was to assess the level, sources, and need for information about dental implants among a selected sample of dental patients in Riyadh, Saudi Arabia.
Sulieman Al-Johany   +3 more
doaj  

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen   +11 more
wiley   +1 more source

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