Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang +32 more
wiley +1 more source
Fitting Accuracy and Constraint Force Measurement of Complete-Arch Implant-Supported Fixed Dental Prostheses Made from Cobalt-Chromium and Zirconia Frameworks Based on the All-on-Four Treatment Concept. [PDF]
Horsch L +5 more
europepmc +1 more source
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang +6 more
wiley +1 more source
Patient-Reported Outcomes of Digital Versus Conventional Impressions for Implant-Supported Fixed Dental Prostheses: A Systematic Review and Meta-Analysis. [PDF]
Pachiou A +7 more
europepmc +1 more source
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source
Digital Impressions for Customized Post-and-Core Restorations in Deep and Narrow Canals: A Case Report Utilizing Scan Posts. [PDF]
Lin L, Cai P, Zheng Z, Zheng Z, Lin J.
europepmc +1 more source
An unusual foreign body in the maxillary sinus: Dental impression material
Yeşim Deniz, AZ Zengin, Rıfat Karlı
openalex +1 more source
Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
Rapid Manufacturing of Dental Prostheses by means of Selective Laser Sintering/Melting [PDF]
Kruth, J.P. +4 more
core +2 more sources

