Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Accuracy and precision of an intraoral scanner in complex prosthetic rehabilitations: an in vitro study [PDF]
The main purpose of this study is to measure the accuracy and the precision of the intraoral optical scanner CS3500® (Carestream Dental LLC, Atlanta, USA) in complex clinical situations as full arch rehabilitations on impl ants.
BRAUNER, EDOARDO +5 more
core
Preformed metal crowns for decayed primary molar teeth [PDF]
BackgroundPreformed metal crowns (PMCs) are recommended by the British Society of Paediatric Dentistry (BSPD) for restoring badly broken down primary molar teeth.
Evans, Dafydd J. P. +2 more
core +3 more sources
Development of human monoclonal antibodies against TARM1 by yeast display
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
The effect of disinfectants on dimensional stability of addition and condensation silicone impressions [PDF]
Background/Aim. Dimensional stability and accuracy of an impression after chemical disinfection by immersion in disinfectants are crucial for the accuracy of final prosthetic restorations.
Sinobad Tamara +6 more
doaj +1 more source
Accuracy and Precision of Occlusal Contacts of Stereolithographic Casts Mounted by Digital Interocclusal Registrations [PDF]
Statement of problem Little peer-reviewed information is available regarding the accuracy and precision of the occlusal contact reproduction of digitally mounted stereolithographic casts.
Bansal, Naveen K. +3 more
core +1 more source
New ophthalmosaurid ichthyosaurs from the European lower cretaceous demonstrate extensive ichthyosaur survival across the Jurassic–Cretaceous boundary [PDF]
Background Ichthyosauria is a diverse clade of marine amniotes that spanned most of the Mesozoic. Until recently, most authors interpreted the fossil record as showing that three major extinction events affected this group during its history: one ...
A Sirotti +91 more
core +6 more sources
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Mishmash Impression Technique for Managing Maxillary Anterior Fibrous Ridge [PDF]
Introduction: Flabby or fibrous ridge is one of the consequences of long term wearing of complete dentures. It can develop where hyperplasic soft tissue replaces the alveolar bone and is a common finding, particularly in the upper anterior region of long
Poonam Kulkarni +3 more
doaj +1 more source

