Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Subicular Astrocytes Govern Seizure‐Impaired Fear Memory
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao +15 more
wiley +1 more source
The effect of regular dental cast artifacts on the 3D superimposition of serial digital maxillary dental models. [PDF]
Henninger E +3 more
europepmc +1 more source
Factors associated with dental care utilization among Iranian adult populations based on Anderson model [PDF]
Ashkan Negintaji Zardak +4 more
openalex +1 more source
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing +10 more
wiley +1 more source
A comparison of patient experience, chair-side time, accuracy of dental arch measurements and costs of acquisition of dental models. [PDF]
Glisic O, Hoejbjerre L, Sonnesen L.
europepmc +1 more source
Evaluation of software developed for automated segmentation of digital dental models.
Joe Min Moon
openalex +1 more source
Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee +6 more
wiley +1 more source
Accuracy evaluation of dental models manufactured by CAD/CAM milling method and 3D printing method. [PDF]
Jeong YG, Lee WS, Lee KB.
europepmc +1 more source

