Results 221 to 230 of about 1,123,990 (335)

Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation

Advanced Science, EarlyView.
TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Zhesong Deng, Jinkun Chen, Ruonan Yang, Yuan Zhan, Shanshan Chen, Jiaheng Zhang, Hao Fu, Yiya Gu, Qian Huang, Jixing Wu, Lianyu Shan, Abdelilah Soussi Gounni, Jungang Xie   +12 more
wiley   +1 more source

Finite element modelling of anterior dental loading in modern human and Neanderthal mandibles [PDF]

, 2008
Flora Gröning, Paul O’Higgins
openalex  

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

Advanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma, Chen Lei, Tao Ye, Qian‐Qian Wan, Kai‐Yan Wang, Yi‐Na Zhu, Ling Li, Xu‐Fang Liu, Long‐Zhang Niu, Franklin R. Tay, Zhao Mu, Kai Jiao, Li‐Na Niu   +12 more
wiley   +1 more source

Developing and Pretesting Case Studies in Dental and Dental Hygiene Education: Using the Diffusion of Innovations Model [PDF]

, 2012
Deborah Cragun, Rita DeBate, Herbert H. Severson, Tracy Shaw, Steve Christiansen, Anne Koerber, Scott L. Tomar, Kelli McCormack Brown, Lisa A. Tedesco, William D. Hendricson   +9 more
openalex   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Erratum to: Immortalized gingival fibroblasts as a cytotoxicity test model for dental materials [PDF]

, 2012
Rasika P. Illeperuma, Young J. Park, Jin M. Kim, Jung Yoon Bae, Mengjun Zhong, Hwa Kyung Son, Mi Ra Han, Kwang‐Mahn Kim, Jin Seok Kim   +8 more
openalex   +1 more source

Multi‐Shank 1024 Channels Active SiNAPS Probe for Large Multi‐Regional Topographical Electrophysiological Mapping of Neural Dynamics

Advanced Science, EarlyView.
This research article introduces a novel CMOS neural probe with 1024 channels distributed across eight shanks. The SiNAPS probe allows for the simultaneous recording of both local field potentials and action potentials in large brain areas. The probe's design allows for detailed mapping and linking neural dynamics and population unit activity, as ...
Gian Nicola Angotzi, Mihály Vöröslakos, Nikolas Perentos, Joao Filipe Ribeiro, Matteo Vincenzi, Fabio Boi, Aziliz Lecomte, Gabor Orban, Andreas Genewsky, Gerrit Schwesig, Deren Aykan, György Buzsáki, Anton Sirota, Luca Berdondini   +13 more
wiley   +1 more source

Evaluation of Three-Dimensional Digital Models Formulated From Direct Intra-oral Scanning of Dental Arches in Comparison With Extra-oral Scanning of Poured Dental Models in Terms of Dimensional Accuracy and Reliability. [PDF]

Cureus
Jaber ST, Hajeer MY, Alkhouli KW, Al-Shamak RM, Darwich KMA, Aljabban O, Alam MK, Kara-Boulad JM.   +7 more
europepmc   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source