Results 81 to 90 of about 2,364,688 (269)

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Frequency of middle mesial canals in mandibular first molars in North Indian population - An in vivo study

Saudi Endodontic Journal, 2016
Objectives: The primary aim of the study was to determine the frequency of middle mesial (MM) canals in mandibular first molars in North Indian population.
Osama Adeel Khan Sherwani, Ashok Kumar, Rajendra Kumar Tewari, Surendra Kumar Mishra, Syed Mukhtar Un Nisar Andrabi, Sharique Alam   +5 more
doaj   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Navigating and Managing Eight Canals in a Maxillary First Molar: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Understanding the existence of an additional root and atypical root canal anatomy is essential because it impacts the manner in which endodontic therapy occurs.
Harsha Nihalani, Anamika C Borkar, Soumya Sharath Shetty, Ajit Hindlekar, Komal Gupta   +4 more
doaj   +1 more source

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

A maxillary first molar with six root canals

Saudi Endodontic Journal, 2014
The purpose of this article is to describe a clinical case of a maxillary first molar with three roots and six root canals.The clinical detection of the six canals was made using a dental operating microscope and confirmed using multiple angled ...
Ranjith Karaththodiyil, Jojo Kottoor, Joy Mathew, Saira George, Jain Mathew   +4 more
doaj   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Obturation quality analysis of furcation perforations repaired with different magnifications and biomaterials

BMC Oral Health
Introduction This study aimed to evaluate the obturation quality of furcation perforations repaired using two different calcium silicate-based materials under two different magnification levels, using micro-computed tomography analysis.
Mustafa Mert Tulgar, Yağmur Kılıç, Merve Işık Aydın, Ali Keleş   +3 more
doaj   +1 more source

Application of computed tomography and operating microscope in planning and performing of endodontic treatment. Analysis of clinical cases

Эндодонтия Today, 2020
Application of computed tomography and dental microscope Carl Zeiss OPMI pico in endodontics, in addition to generally used methods, allows to perform accurate diagnostics and choose the most suitable method of treatment.

doaj