Results 41 to 50 of about 1,026,292 (304)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Critical Literature Synthesis of Low-Income Oral Health Disparities in the United States and Interventions for Improved Access to Care [PDF]

, 2011
Over a decade ago the United States Surgeon General released a report about oral health in America which highlighted the disparities that exist between high and low-income populations.
Lubiejewski, Sarah
core  

Meeting report: a hard look at the state of enamel research. [PDF]

, 2017
The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines (ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research (NIDCR).
Bartlett, John D, DenBesten, Pamela, Diekwisch, Thomas Gh, Duverger, Olivier, Joester, Derk, Klein, Ophir D, Kulkarni, Ashok B, Lacruz, Rodrigo S, Millar, Sarah E, Moradian-Oldak, Janet, Pugach, Megan K, Shaw, Wendy, Simmer, James P, Wright, J Timothy   +13 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Advanced Ceramic Materials and Processes for Three-Dimensional Printing (3DP) [PDF]

, 2006
The University of Washington and ExOne, Inc. are collaborating in the development of advanced ceramic materials and processes for three-dimensional printing (3DP).
Anderson, Rhonda L., Kuhn, Howard, Utela, Ben   +2 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Dental Student Engagement in Research: A Survey of California Dental Schools

Journal of the California Dental Association
Objective Research engagement is a vital component of dental education, fostering the development of evidence-based practices and advancing the field of dentistry.
Anthony Nguyen, Jocelyn B. Chen, Rachel J. Kulchar, Yvonne L. Kapila   +3 more
doaj   +1 more source

Effectiveness, cost-effectiveness and cost-benefit of a single annual professional intervention for the prevention of childhood dental caries in a remote rural Indigenous community [PDF]

, 2015
Background The aim of the study is to reduce the high prevalence of tooth decay in children in a remote, rural Indigenous community in Australia, by application of a single annual dental preventive intervention.
A Ahovuo-Saloranta, A Tam, Australian Institute of Aboriginal and Torres Strait Islander Studies, Australian Institute of Health and Welfare, BF Gooch, BL Pihlstrom, FJ Ramos-Gomez, GC Mejia, GD Slade, J Abanto, JA Aas, JA Weintraub, Jeroen Kroon, JJ Caro, JM Tanzer, JY Lee, K Gabris, K Pieper, K Roberts-Thomson, KF Roberts-Thomson, KJ Stevens, L Lopez, L Zhan, Lisa M. Jamieson, LJ Walsh, M Bonecker, MF Savage, MM Braga, MS Skeie, National Health & Medical Research Council, Newell W. Johnson, NW Johnson, Ohnmar Tut, OK Tut, Paul A. Scuffham, PL Rouxel, PM Milgrom, PS Ollila, Ratilal Lalloo, RH Selwitz, RJ Berkowitz, RJ Marino, Robyn Boase, S Gherunpong, S Krisdapong, S Kumar, Sanjeewa Kularatna, Surani Fernando, T Vos, Valda Wallace, VC Marinho, W Marcenes, Yvonne Cadet-James   +52 more
core   +4 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Research Publication Challenges Faced by Dentists in India: A Narrative Review of Multilevel Barriers [PDF]

Journal of Clinical and Diagnostic Research
Research articles are essential for achieving academic excellence, frequently impacting career progression, funding opportunities, and the prestige of educational Institutions.
K Saran, G Krishnaprakash, Sibyl Siluvai, Kp Indumathi   +3 more
doaj   +1 more source