Results 91 to 100 of about 50,286 (298)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin   +9 more
wiley   +1 more source

AESTHETIC CONCEPTS IN CONTEMPORARY DENTAL MEDICINE

open access: yesRomanian Journal of Oral Rehabilitation, 2014
In our days, the aim of the dental medicine is not only to realize functional restoration, but also aesthetic prosthesis. Modern materials and emerging peak technologies allow today's dental restorations achievement that meets the highest aesthetic ...
Diana Antonela Diaconu   +2 more
doaj  

THE USE OF CAD/CAM TECHNOLOGIES IN MINIMALLY INVASIVE DENTAL RESTORATIONS: A SYSTEMATIC REVIEW

open access: yesRomanian Journal of Oral Rehabilitation
Aim of the study The study reviews dental treatment effectiveness, CAD/CAM technology compatibility, and restorative materials’ clinical performance, focusing on demographics, criteria, interventions, methodologies, and outcomes across countries and ...
Nadiia Melnyk   +4 more
doaj   +1 more source

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

open access: yesAdvanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin   +6 more
wiley   +1 more source

p21 regulates the migration and polarization of macrophages in diabetic tooth extraction wound by regulating periodontal ligament fibroblasts

open access: yesKouqiang hemian waike zazhi
[Objective:] To explore the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) in the healing process of tooth extraction wounds in diabetic mice and the effect on migration and polarization of macrophages.
ZHU Jiayu   +5 more
doaj   +1 more source

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