Results 141 to 150 of about 128,639 (365)

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, EarlyView.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Survival and causes of failed amalgam restorations

Journal of Bahria University Medical and Dental College, 2014
Objective: To determine the reasons for failure of amalgam restorations and evaluate the association between the reasons for failure of restorations with gender, classes of cavities, and teeth involved.
Shama Asghar, Farheen Fatima
doaj  

Different Methods to Salvage the Fractured Abutment Screws and Potential Reasons of Abutment Screw Loosening: A Narrative Review

Journal of Pharmacy and Bioallied Sciences
Dental implant restoration is a popular therapy for replacing lost teeth and regaining human masticatory function. However, studies have shown prosthetic problems like implant fracture, screw loosening, and screw fracture. Abutment screw loosening is the
Prajakta Gir, Snehal Joshi, V Vishnupriya, Ashlesha Marathe, Abhishek Bagul, Girish Nazirkar   +5 more
doaj   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

Advanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang   +20 more
wiley   +1 more source

Visualization of interfacial adhesive defects at dental restorations with spectral domain and polarization sensitive optical coherence tomography

Current Directions in Biomedical Engineering, 2018
Restoration loss based on interfacial adhesive defects and associated caries at the restoration margin are the main causes for invasive replacement of dental restorations.
Tetschke Florian, Golde Jonas, Walther Julia, Kirsten Lars, Koch Edmund, Hannig Christian, Rüger Claudia, Schneider Hartmut, Haak Rainer   +8 more
doaj   +1 more source

Mercury or Mercury Free Restorations in Oral Cavity [PDF]

, 2018
Amalgam is basically a concoction of metals that has been used as a potent filling material in dentistry for the last 150 years. Amalgam usually consists of silver, mercury, tin and copper.
Chaurasia, A. (Akhilanand), Tiwari, R. (Rini), Verma, U. P. (Umesh), Yadav, R. K. (Rakesh)   +3 more
core  

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, Volume 12, Issue 28, July 24, 2025.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Retrospective Analysis of Dental Implants Placed Between 2012 and 2014: Indications, Risk Factors, and Early Survival.

The International Journal of Oral and Maxillofacial Implants, 2017
PURPOSE The aim of this study was to review the indications for implant placement, early outcomes, and associated risk factors. MATERIALS AND METHODS A retrospective cohort study design was used.
K. Grisar, D. Sinha, J. Schoenaers, T. Dormaar, C. Politis   +4 more
semanticscholar   +1 more source