Results 261 to 270 of about 299,655 (336)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Assessment of the biomechanical performance of digitally manufactured space maintainers: a finite element analysis. [PDF]

Sci Rep
Karahan M, Kızıltan Elıacık BB, Yuzbasıoglu B, Korkmaz B, Guzelce Sultanoglu E.   +4 more
europepmc   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

Effects of Passiflora incarnata on salivary biomarkers and anxiety in patients undergoing third molar extraction surgery. [PDF]

Sci Rep
Lima Neto TJ, Ribeiro NP, Souza MB, Freitas RN, Karande S, Mourão CF, Chaves-Neto AH, Faverani LP.   +7 more
europepmc   +1 more source

Prevalence and Incidence of Stress Among UK Dental Students: A Systematic Review and Meta-analysis

Sultan Alotaibi, Eleni Deligianni, Philip Riley, Anne‐Marie Glenny   +3 more
openalex   +1 more source

OS1001 Stress analysis of human mandible based on micro CT and dental conebeam CT images

, 2009
Tatsuya Matsuzaki, Naoki Takano, Satoru Matsunaga, Yoshinobu Ide   +3 more
openalex   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Biomechanical Analysis of Customized 3D-Printed Orthodontic Archwires Using Finite Element Modeling and Clinical Validation.

J Pharm Bioallied Sci
Alam MK, Hajeer MY, Alsalamah NA, AlMunasser LS, Alotaibi GY, Rashid ME.   +5 more
europepmc   +1 more source

Biomechanical evaluation of prosthetic framework materials in subperiosteal implants: a finite element analysis. [PDF]

BMC Oral Health
Demir B, Caglar I.
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source