Results 81 to 90 of about 3,549 (275)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Frequency and distribution of developmental anomalies in the permanent teeth of a Turkish orthodontic patient population

Journal of Dental Sciences, 2011
Background/purpose: The aims of this study were to determine the frequency and distribution of developmental anomalies in the permanent teeth of a Turkish orthodontic patient population and determine the relationships between gender and dental anomalies.
Fatih Kazanci, Mevlut Celikoglu, Ozkan Miloglu, Ismail Ceylan, Hasan Kamak   +4 more
doaj   +1 more source

Interface Wettability Transition‐Driven Drug Release and Dual‐Phase Functionalization in Implant Abutment

Advanced Science, EarlyView.
A temporally controlled drug release coating is developed for abutments using a superhydrophobic coating self‐assembled on mesoporous silica. This surface provides sequential functionality: initial contamination resistance through non‐wetting, followed by controlled drug release via wettability transition.
Zhongchao Wang, Liang Shi, MingXia Li, Xiao Han, Jinghan Wang, Guangping Wang, Dan Zou, Bingyang Lu, Liyuan Fan   +8 more
wiley   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Traction Of Multiple Impacted Maxillary Teeth With Root Transposition

International Dental Journal
Introduction: This report presents an 8-year-old male with skeletal Class I malocclusion and multiple mesioangular-horizontal high-position impacted permanent teeth (#11, #12, #13) accompanied by 12-13 root transposition in the maxillary anterior region.
Weiqian Zeng, Yajing Fu, Biyun Gao, Jun Zhang, Jing Hu   +4 more
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Canine transposition as an alternative to trauma of the maxillary incisors: case report

, 2018
Objective: The present article aims at reporting the clinical case of a patient who suffered trauma at two years of age, causing almost complete apical displacement of the deciduous maxillary left central incisor and of the permanent incisor.
Rocío Briones Rodríguez (5835599), Solano Mendoza, Beatriz, María Biedma Perea (5835602), María Salcedo Lara (5835596), Beatriz Solano Mendoza (5835605), Salcedo Lara, María, Biedma Perea, María, Briones Rodríguez, Rocío   +7 more
core   +1 more source

Early mandibular canine-lateral incisor transposition: case report [PDF]

, 2017
Purpose. The main aim of the present study is to present a case of mandibular transposition between lateral incisor and canine in a paediatric patient. Materials and methods.
Lacarbonara, V., Pettini, F., Rapone, B., Corsalini, M., Grassi, F. R., Laforgia, A., Stefanachi, G., Nardi, G. M., Rapone, Biagio, Di Venere, D.   +9 more
core   +1 more source

Dental Transposition Of Mandibular Canine And First Premolar – The First Case Report

, 2014
Dental transposition is a form of ectopic eruption with change in position of normal adjacent teeth. Its prevalence is very low in general population and could be frequently missed on oral examination. We present a rare case of dental transposition between left mandibular canine and first premolar in a 22 year old Libyan male patient.
Ramalingam , K. , , Sethuraman, S. ,, Awidat , K, Basheer , O.   +3 more
openaire   +2 more sources

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source