Results 231 to 240 of about 812,397 (317)

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du   +8 more
wiley   +1 more source

Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
This study reveals that in alveolar macrophages of high‐fat diet‐induced obese mice, the transcriptional repressor GFI1 is upregulated. This upregulation suppresses ACOD1 expression, which intensifies lipopolysaccharide‐induced lung inflammation and oxidative stress, thereby worsening acute lung injury. Abstract To investigate the mechanisms behind the
Jingyue Ma   +11 more
wiley   +1 more source

The Evaluation of Oral Health in Patients Undergoing Dental Treatment During the COVID-19 Pandemic. [PDF]

open access: yesJ Clin Med
Bielecki-Kowalski B   +5 more
europepmc   +1 more source

Temporal Association Cortex Gates Sound‐Evoked Arousal from NREM Sleep

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
It is often wondered why some sounds wake people while others don't. Researchers have discovered that the temporal association cortex plays a key role in this during NREM sleep. Neurons in this region work with the amygdala to decide which sounds are important enough to interrupt sleep, providing a balance between rest and responsiveness.
Haipeng Yu   +20 more
wiley   +1 more source

Patients with severe odontogenic infections receive insufficient dental treatment before hospitalization - a retrospective cross-sectional study. [PDF]

open access: yesActa Odontol Scand
Søndenbroe R   +7 more
europepmc   +1 more source

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