Results 41 to 50 of about 96,977 (302)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Effect of Dentin Wetness on the Bond Strength of Universal Adhesives

Materials, 2017
The effects of dentin wetness on the bond strength and adhesive interface morphology of universal adhesives have been investigated using micro-tensile bond strength (μTBS) testing and confocal laser scanning microscopy (CLSM).
An-Na Choi, Ji‐hye Lee, Sung-Ae Son, Kyoung-Hwa Jung, Y. Kwon, Jeong-Kil Park   +5 more
semanticscholar   +1 more source

Crack Repair in Hydroxyapatite Bioceramics Using an Ultraviolet Ultrafast Laser

Advanced Materials Interfaces, EarlyView.
The study proposes an ultrafast ultraviolet laser approach to repair hidden tooth cracks, which has been preliminarily validated on HAP. Moreover, this technique aims to strengthen the native enamel structure rather than introducing a foreign filling material.
Yan Xue, Kai Zheng, Yang Liao, Jing Cao, Xupeng Yuan, Fusong Yuan, Yuxin Leng   +6 more
wiley   +1 more source

Haploinsufficiency of Dspp Gene Causes Dentin Dysplasia Type II in Mice

Frontiers in Physiology, 2020
Dentin dysplasia (DD) and dentinogenesis imperfecta (DGI) patients have abnormal structure, morphology, and function of dentin. DD-II, DGI-II, and DGI-III are caused by heterozygous mutations in the dentin sialophosphoprotein (DSPP) gene in humans ...
Ce Shi, Ce Shi, Ning Ma, Wei Zhang, Jiapeng Ye, Jiapeng Ye, Haibo Shi, Haibo Shi, Danwei Xiang, Danwei Xiang, Chunyue Wu, Chunyue Wu, Lina Song, Lina Song, Ning Zhang, Ning Zhang, Qilin Liu, Qilin Liu   +17 more
doaj   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Bone Regeneration Using Dentin Matrix Depends on the Degree of Demineralization and Particle Size

PLoS ONE, 2016
Objectives This study aimed to examine the influence of particle size and extent of demineralization of dentin matrix on bone regeneration. Materials and Methods Extracted human teeth were pulverized and divided into 3 groups according to particle size ...
T. Koga, T. Minamizato, Y. Kawai, K. Miura, T. I, Y. Nakatani, Y. Sumita, I. Asahina   +7 more
semanticscholar   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization

Scientific Reports
Dentin sialophosprotein (DSPP) is cleaved into the N-terminal dentin sialoprotein (DSP) proteoglycan and the C-terminal dentin phosphoprotein (DPP; the most acidic proteins in humans).
Tian Liang, Charles E. Smith, Yuanyuan Hu, Hong Zhang, Chuhua Zhang, James P. Simmer, Jan C.-C. Hu   +6 more
doaj   +1 more source

Effects of Dentifrices Containing Nanohydroxyapatite on Dentinal Tubule Occlusion—A Scanning Electron Microscopy and EDX Study

Applied Sciences, 2020
This in vitro study evaluated the effects of dentifrices containing nano-hydroxyapatite (n-HAp) on dentinal tubule occlusion and on mineral deposition.
Emilia Bologa, Simona Stoleriu, Gianina Iovan, Cristina Angela Ghiorghe, Irina Nica, Sorin Andrian, Oana Elena Amza   +6 more
doaj   +1 more source