Results 51 to 60 of about 2,152 (168)

Evaluation of dental manifestations in X-linked hypophosphatemia using orthopantomography.

PLoS ONE
BackgroundX-linked hypophosphatemia (XLH) is the most common inherited form of rickets. The presence of sequence variations in the phosphate regulating endopeptidase homolog X-linked (PHEX) gene is associated with increased production of fibroblast ...
Rena Okawa, Misato Takagi, Takashi Nakamoto, Naoya Kakimoto, Kazuhiko Nakano   +4 more
doaj   +1 more source

Kdf1 Regulates Molar Cusp Morphogenesis via the PI3K/AKT/mTOR Signalling Axis

Cell Proliferation, Volume 59, Issue 3, March 2026.
Epithelial Kdf1 knockout disrupts molar cusp morphogenesis by promoting inner enamel epithelium proliferation and invagination via PI3K/AKT/mTOR signalling. ABSTRACT Keratinocyte differentiation factor 1 (Kdf1) reportedly plays a significant role in enamel formation.
Jiayu Wang, Miao Yu, Hangbo Liu, Kai Sun, Chenxin Geng, Haochen Liu, Hailan Feng, Yang Liu, Hu Zhao, Dong Han   +9 more
wiley   +1 more source

Deficiency of Mineralization-Regulating Transcription Factor Trps1 Compromises Quality of Dental Tissues and Increases Susceptibility to Dental Caries

Frontiers in Dental Medicine, 2022
Dental caries is the most common chronic disease in children and adults worldwide. The complex etiology of dental caries includes environmental factors as well as host genetics, which together contribute to inter-individual variation in susceptibility ...
Mairobys Socorro, Priyanka Hoskere, Catherine Roberts, Lyudmila Lukashova, Kostas Verdelis, Kostas Verdelis, Kostas Verdelis, Elia Beniash, Elia Beniash, Dobrawa Napierala, Dobrawa Napierala   +10 more
doaj   +1 more source

Reflections of Their Homelands—Early Life Enamel Formation Disruption in Nineteenth Century Settlers of Otago, New Zealand

Journal of the Royal Society of New Zealand, Volume 56, Issue 1, February 2026.
Physiological stress during early life can impede development, and signals of this are preserved in nonremodelling tissues such as dental enamel. This article describes nonspecific stress markers in the teeth of European (n = 30) and Southern Chinese (n = 15) adult migrants to New Zealand, and colony‐born children (n = 10) interred in four historic ...
Lucy A. Kavale‐Henderson, Carolina Loch, Hallie Buckley, Peter Petchey, Charlotte King, Claire Cameron, Anne Marie E. Snoddy   +6 more
wiley   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, Volume 13, Issue 4, 19 January 2026.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Bilateral Symmetrical Fusion of Permanent Mandibular Lateral Incisors and Canines: A Rare Clinical Case

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Fusion is a rare developmental anomaly characterized by the union of two adjacent tooth germs during the morphodifferentiation stage of tooth formation, resulting in a single enlarged tooth. Its prevalence ranges from 0.4% to 0.9% in the primary dentition and approximately 0.2% in the permanent dentition.
Suresh Kandagal Veerabhadrappa, Jayanth Kumar Vadivel, Mohamed Zahoor Ul Huqh, Siddharthan Selvaraj, Anand Marya, Seema Yadav   +5 more
wiley   +1 more source

ISOLATED DENTINOGENESIS IMPERFECTA AND IN ASSOCIATION WITH OSTEOGENESIS IMPERFECTA – A LITERATURE REVIEW [PDF]

Romanian Medical Journal, 2018
Dental development is part of the craniofacial organogenesis, starting from the pluripotent cephalic neural crest cells, continuing with their movement towards the first pharyngeal arch and leading to the development of many elements of the ...
Andrei Kozma, Doriana Agop Forna, Viorica Radoi, Ana Maria Alexandra Stanescu, Radu Ursu, Laurentiu Camil Bohaltea   +5 more
doaj   +1 more source

Dentin dysplasia type 1 - clinical management dilemmas: A case report of first-generation sufferers

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2018
Dentine Dysplasia is a rare genetic condition. The treatment options and dilemmas associated with the condition remain undiscovered so far. This article highlights the variations in traits and challenges faced in the treatment of the cases.
Navneet Grewal, Samita Gumber, Anupam Kaur, Nirapjeet Kaur   +3 more
doaj   +1 more source

Current Landscape of Short‐T2 Imaging Techniques in the Musculoskeletal System: The Past, Present and Future

Journal of Magnetic Resonance Imaging, Volume 62, Issue 4, Page 969-985, October 2025.
ABSTRACT Conventional MRI is limited in imaging tissues with short T2 relaxation times, such as bone, ligaments, and cartilage, due to their rapid signal decay. This limitation has spurred the development of specialized MRI techniques designed specifically for short‐T2 tissue imaging.
Pranjal Rai, Amit Kumar Janu, Nitin Shetty, Suyash Kulkarni   +3 more
wiley   +1 more source

Pulp Stone Formation Following Fixed Orthodontic Treatment: A Panoramic Radiographic Comparison of Extraction and Non‐Extraction Approaches

Clinical and Experimental Dental Research, Volume 11, Issue 4, August 2025.
ABSTRACT Objective The impact of orthodontic forces on pulp stone formation has been the focus of several studies. Given that orthodontic extractions typically involve the application of greater forces to the teeth, the aim of this study was to compare the extent of pulp stone formation in the molar teeth of patients undergoing orthodontic treatment ...
Kosar Gholinezhad, Hakimeh Ghorbani, Seyedali Seyedmajidi, Sedigheh Sheikhzadeh, Manouchehr Rahmati Kamel   +4 more
wiley   +1 more source