Results 1 to 10 of about 20,792 (192)

Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections. [PDF]

PLoS Pathogens, 2021
Dengue human infection studies present an opportunity to address many longstanding questions in the field of flavivirus biology. However, limited data are available on how the immunological and transcriptional response elicited by an attenuated challenge
Adam T Waickman, Heather Friberg, Gregory D Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G Jarman, Stephen J Thomas, Alan L Rothman, Timothy Endy, Jeffrey R Currier   +15 more
doaj   +6 more sources

Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR [PDF]

Microorganisms, 2021
Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011.
Elodie Calvez, Phaithong Bounmany, Charlotte Balière, Somphavanh Somlor, Souksakhone Viengphouthong, Thonglakhone Xaybounsou, Sitsana Keosenhom, Kitphithak Fangkham, Paul T. Brey, Valérie Caro, Vincent Lacoste, Marc Grandadam   +11 more
doaj   +6 more sources

Immunoinformatics study to explore dengue (DENV-1) proteome to design multi-epitope vaccine construct by using CD4+ epitopes. [PDF]

J Genet Eng Biotechnol, 2023
Immunoinformatics is an emerging interdisciplinary field which integrates immunology, bioinformatics, and computational biology to study the immune system. In this study, we apply immunoinformatics approaches to explore the dengue proteome in order to design a multi-epitope vaccine construct.We used existing databases and algorithms to predict ...
Bano N, Kumar A.
europepmc   +5 more sources

DENV-1 and DENV-2 more prevalent in dengue-dominated Southeast Asia as a natural geographic cluster. [PDF]

Ann Med Surg (Lond)
Chakraborty C, Bhattacharya M, Islam MA, Agoramoorthy G.   +3 more
europepmc   +4 more sources

Spatiotemporal dispersion of DENV-1 genotype V in Western Colombia. [PDF]

Virus Evol
Abstract Dengue virus (DENV) is a significant public health concern in Colombia, with increased transmission of DENV type 1 (DENV-1) in the departments of Risaralda and Valle del Cauca in the Central-West region of the country following a large outbreak in 2019.
Rojas-Gallardo D, Ferrell T, Escobar-Pereira PM, Lopez D, Giraldo B, Restrepo-Chica J, Jimenez-Posada E, Martinez-Gutierrez M, Ruiz-Sáenz J, Key A, Shariatzadeh N, Khosravi D, Martinez MA, Bombin A, Waggoner JJ, Osorio JE, Neufeldt CJ, Collins MH, Cardona-Ospina JA, Piantadosi A.   +19 more
europepmc   +5 more sources

DENV-1 Titer Impacts Viral Blocking in wMel Aedes aegypti with Brazilian Genetic Background. [PDF]

Viruses
Several countries have been using Wolbachia deployments to replace highly competent native Aedes aegypti populations with Wolbachia-carrying mosquitoes with lower susceptibility to arboviruses such as dengue, Zika, and chikungunya. In Rio de Janeiro, Wolbachia deployments started in 2015 and still present a moderate introgression with a modest ...
Corrêa-Antônio J, David MR, Couto-Lima D, Garcia GA, Keirsebelik MSG, Maciel-de-Freitas R, Pavan MG.   +6 more
europepmc   +6 more sources

DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016. [PDF]

Sci Rep, 2018
AbstractIn Brazil, DENV-1 introduced in the 80’s, remained the prevalent serotype from 2012 to 2016. After its re-emergence in the country in 2009, the co-circulation of different viral lineages was identified, however, its transmission dynamics afterwards, was not fully characterized.
de Bruycker-Nogueira F, Souza TMA, Chouin-Carneiro T, da Costa Faria NR, Santos JB, Torres MC, Ramalho ILC, de Aguiar SF, Nogueira RMR, de Filippis AMB, Dos Santos FB.   +10 more
europepmc   +5 more sources

DENV-1 Infection of Macrophages Induces Pyroptosis and Causes Changes in MicroRNA Expression Profiles. [PDF]

Biomedicines
Background: Dengue virus (DENV) is the most widespread mosquito-borne virus, which can cause dengue fever with mild symptoms, or progress to fatal dengue hemorrhagic fever and dengue shock syndrome. As the main target cells of DENV, macrophages are responsible for the innate immune response against the virus. Methods: In this study, we investigated the
Zhang Q, Yu S, Yang Z, Wang X, Li J, Su L, Zhang H, Lou X, Mao H, Sun Y, Fang L, Yan H, Zhang Y.   +12 more
europepmc   +6 more sources

Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon. [PDF]

Microbiol Spectr, 2023
Hu M, Li WF, Wu T, Yang Y, Chen G, Chen T, Liu Y, Mei Y, Wu, Wei Y, Luo T, Zhang HJ, Li YP.   +12 more
europepmc   +2 more sources

Aged AG129 mice support the generation of highly virulent novel mouse-adapted DENV (1-4) viruses exhibiting neuropathogenesis and high lethality. [PDF]

Virus Res
Siddqui G, Vishwakarma P, Saxena S, Kumar V, Bajpai S, Kumar A, Kumar S, Khatri R, Kaur J, Bhattacharya S, Ahmed S, Syed GH, Kumar Y, Samal S.   +13 more
europepmc   +2 more sources