Results 151 to 160 of about 23,915,363 (231)

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Phylodynamics of DENV-1 reveals the spatiotemporal co-circulation of two distinct lineages in 2013 and multiple introductions of dengue virus in Goiás, Brazil

Infection, Genetics and Evolution, 2016
Dengue virus type 1 (DENV-1) was the first serotype introduced in Brazil, during in the 1980s. Since then, this virus has spread in the Brazilian territory, causing several outbreaks. In 2013 the highest number of dengue cases was notified, when compared to the previous years in Brazil, and the state of Goiás reported over 160 thousand cases.
Menira Souza, Thaís Santana de Oliveira, Tâmera Nunes Vieira Almeida, Fabíola Souza Fiaccadori, Vanessa Neiva Guimarães, Marielton dos Passos Cunha, Divina das Dôres de Paula Cardoso   +6 more
openaire   +3 more sources

Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity?

Immunology, Volume 176, Issue 3, Page 312-321, November 2025.
Immunoglobulin E has been extensively studied in allergies and parasitic diseases. Antigen‐specific IgE has been identified as part of the humoral response to viruses. This revision speculates on possible functionalities for IgE, such as neutralisation, cytotoxicity and immunopathology of viral diseases, and provide insights about gaps to fill in ...
Amanda Izeli Portilho, Valéria Oliveira Silva, Luis Fernando de Macedo Brigido, Elizabeth De Gaspari   +3 more
wiley   +1 more source

Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans.

PLoS Neglected Tropical Diseases, 2012
The four dengue virus serotypes (DENV-1-DENV-4) have a large impact on global health, causing 50-100 million cases of dengue fever annually. Herein, we describe the first kinetic T cell response to a low-dose DENV-1 vaccination study (10 PFU) in humans ...
Janet C Lindow, Nathan Borochoff-Porte, Anna P Durbin, Stephen S Whitehead, Kelly A Fimlaid, Janice Y Bunn, Beth D Kirkpatrick   +6 more
doaj   +1 more source

Pantinin‐Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
Pantinin‐1 and pantinin‐2, scorpion venom–derived peptides, show potent antiviral activity against caprine and bovine herpesviruses. Acting via virucidal action and inhibition of viral entry/fusion, they adopt α‐helical structures in membrane‐mimetic environments. These structure–activity insights highlight their potential as therapeutic agents against
Rosa Giugliano, Carla Zannella, Annalisa Chianese, Clementina Acconcia, Alessandra Monti, Roberta Della Marca, Ugo Pagnini, Serena Montagnaro, Nunzianna Doti, Carla Isernia, Massimiliano Galdiero, Filomena Fiorito, Luigi Russo, Valentina Iovane, Anna De Filippis   +14 more
wiley   +1 more source

Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Ionizing radiation disrupts gut virome and bacteriome. Gut commensal viruses protect against intestinal damage and promote stem cell regeneration by inhibiting hyperactivation of RIG‐I and Notch signaling in stem cells. Fecal virome transplantation (FVT) from healthy donors can serve as a potential therapeutic intervention by enriching phages targeting
Xiaotong Zhao, Yu Cai, Yujia Hou, Yanjin Wu, Tingting Wei, Lili Li, Zhaojun Duan, Xinran Lu, Jiahui Meng, Haitao Zhou, Qin Wang, Jinhan Wang, Chang Xu, Liqing Du, Saijun Fan, Feng Wang, Qiang Liu, Yang Liu   +17 more
wiley   +1 more source

The Sweet Aspects of Orthoflavivirus Treatment Design and Vaccine Development

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Viruses in the genus Orthoflavivirus are among the most important human pathogens because of their significant public health impact. Many strategies have been proposed to develop specific or broad‐spectrum treatments and preventive measures for these viral infections in humans.
Ana C. Alcalá, Michelle Gutiérrez, Juan E. Ludert   +2 more
wiley   +1 more source

Chlamydia trachomatis Biovar L2 Infection in Women in South Africa [PDF]

, 2017
We detected Chlamydia trachomatis biovar L2 in vaginal swab specimens of 7 women with vaginal discharge in South Africa. Whole-genome sequencing directly from clinical specimens identified a closely related cluster of strains.
Breuer, J, Doyle, R, Kock, MM, McIntyre, JA, Peters, RPH, Redelinghuys, MJ, Verjans, GM   +6 more
core  

Lessons learned exploiting a multi‐year large‐scale data set derived from operational quality assessment of mosquito larval treatments in rain catch basins

Pest Management Science, Volume 81, Issue 10, Page 6630-6638, October 2025.
Results highlight opposite associations between percentages of positive rain catch basins treated with diflubenzuron and Bacillus against mosquito larvae and/or pupae and the intervals between treatments and inspections, and spatial variability in vector control.
Chiara Virgillito, Eleonora Longo, Silvia Paolucci, Martina Micocci, Mattia Manica, Federico Filipponi, Stefano Vettore, Davide Bonetto, Andrea Drago, Simone Martini, Alessandra Della Torre, Beniamino Caputo   +11 more
wiley   +1 more source

Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon. [PDF]

Microbiol Spectr, 2023
Hu M, Li WF, Wu T, Yang Y, Chen G, Chen T, Liu Y, Mei Y, Wu, Wei Y, Luo T, Zhang HJ, Li YP.   +12 more
europepmc   +1 more source