Results 51 to 60 of about 20,792 (192)

Profiling an Enhanced IL-6 Expression Distinguishes Host Susceptibility to Primary and Secondary Infections of the Dengue Virus in an Ex Vivo Whole-Blood Coculture Model. [PDF]

J Trop Med
Dengue virus (DENV) infection can potentially lead to severe dengue disease due to the risk of antibody‐dependent enhancement. This study reports a comparative analysis of the host cytokine/chemokine response triggered by primary and secondary DENV infections using an artificial ex vivo whole‐blood coculture model to simulate viremia during the acute ...
Nanda JD, Jhan MK, Satria RD, Wang YT, Ho TS, Sufriyana H, Su EC, Lin CF, Das B.   +8 more
europepmc   +2 more sources

Evolutionary history and spatiotemporal dynamics of DENV-1 genotype V in the Americas

Infection, Genetics and Evolution, 2016
The genotype V has been the most prevalent dengue virus type 1 (DENV-1) clade circulating in the Americas over the last 40years. In this study, we investigate the spatiotemporal pattern of emergence and dissemination of DENV-1 lineages in the continent.
Fernanda, de Bruycker-Nogueira, Daiana, Mir, Flavia Barreto, Dos Santos, Gonzalo, Bello   +3 more
openaire   +2 more sources

Circulating serotypes and genotypes of dengue virus in North India: An observational study

Journal of Vector Borne Diseases
Background & objectives: This study reports observation on circulating serotypes and genotypes of Dengue Virus in North India. Methods: Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2014 to ...
Om Prakash, Anil Kumar Verma, Asutosh Paliwal, Faisal Abbas, Ashish Kumar Srivastava, Vivek Kumar Mishra, Shruti Radera, Amita Jain   +7 more
doaj   +1 more source

Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti.

PLoS Genetics, 2020
Although specific interactions between host and pathogen genotypes have been well documented in invertebrates, the identification of host genes involved in discriminating pathogen genotypes remains a challenge.
Laura B Dickson, Sarah H Merkling, Mathieu Gautier, Amine Ghozlane, Davy Jiolle, Christophe Paupy, Diego Ayala, Isabelle Moltini-Conclois, Albin Fontaine, Louis Lambrechts   +9 more
doaj   +1 more source

Envelope domain III E₃₂₄, E₃₅₁, and E₃₈₀ mutations lever adaptive evolution of DENV-1 genotype I. [PDF]

J Virol
ABSTRACT Dengue virus (DENV) gains genetic mutations during continuous transmission and evolution, making the virus more adaptive and virulent. The clade of DENV-1 genotype I has expanded and become the predominant genotype in Asia and the Pacific areas, but the underlying mechanisms are unclear.
Jiang T, Huang C, Ruan Q, Huang X, Liang C, Chen Z, Yu X, Peng Y, Liu Z, Cheng G, Dai J, Sun J.   +11 more
europepmc   +3 more sources

Genetic Diversity and Spatiotemporal Dynamics of DENV-1 and DENV-2 Infections During the Last Dengue Outbreak in Mexico

SSRN Electronic Journal, 2022
Eduardo D. Rodríguez-Aguilar, Jesús Martínez-Barnetche, Lilia Juárez‐Palma, Alejandro Alvarado‐Delgado, César González-Bonilla, Mario H. Rodrı́guez   +5 more
openalex   +2 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Immunological and viral determinants of dengue severity in hospitalized adults in Ha Noi, Viet Nam. [PDF]

PLoS Neglected Tropical Diseases, 2011
The relationships between the infecting dengue serotype, primary and secondary infection, viremia and dengue severity remain unclear. This cross-sectional study examined these interactions in adult patients hospitalized with dengue in Ha Noi.158 patients
Annette Fox, Nguyen Minh Hoa Le, Cameron P Simmons, Marcel Wolbers, Heiman F L Wertheim, Thi Khuong Pham, Thi Hai Ninh Tran, Thi Minh Lien Trinh, Thi Lien Nguyen, Vu Trung Nguyen, Duc Hien Nguyen, Jeremy Farrar, Peter Horby, Walter R Taylor, Van Kinh Nguyen   +14 more
doaj   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

Advanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng, Xiong Wang, Cien Chen, Di Wang, Changshun Hou, Yiran Wang, Huan Hu, Peiran Chen, LeiYing Qin, Qianya Wan, Xi Yao, Ming‐Liang He   +11 more
wiley   +1 more source

Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia

Infection, Genetics and Evolution, 2013
In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. Since 2000, the Dengue National Control Program has reported from 10,000 to 40,000 cases per year with fatality rates ranging from 0.7 to 1.7.
Duong, Veasna, Simmons, Cameron, Gavotte, Laurent, Viari, Alain, Ong, Sivuth, Chantha, Ngan, Lennon, Niall J., Birren, Bruce W., Vong, Sirenda, Farrar, Jeremy J., Henn, Matthew R., Deubel, Vincent, Frutos, Roger, Buchy, Philippe   +13 more
openaire   +7 more sources