Results 71 to 80 of about 20,792 (192)

Emergence of new genotypes and lineages of dengue viruses during the 2012–15 epidemics in southern India

International Journal of Infectious Diseases, 2019
Objectives: To genotypically characterize dengue virus (DENV) isolates among dengue-infected children from 2012–13/2014–15 outbreaks in southern India.
Syed Fazil Ahamed, Vivek Rosario, Carl Britto, Mary Dias, Kaustuv Nayak, Anmol Chandele, Murali-Krishna Kaja, Anita Shet   +7 more
doaj   +1 more source

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

Advanced Intelligent Discovery, EarlyView.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki, Bassam Bachour Junior, Marcelo Mulato, José Ilton de Oliveira Filho   +3 more
wiley   +1 more source

TIM-1 Ubiquitination Mediates Dengue Virus Entry

Cell Reports, 2018
Summary: Dengue virus (DENV) is a major human pathogen causing millions of infections yearly. Despite intensive investigations, a DENV receptor that directly participates in virus internalization has not yet been characterized.
Ophélie Dejarnac, Mohamed Lamine Hafirassou, Maxime Chazal, Margaux Versapuech, Julien Gaillard, Manuel Perera-Lecoin, Claudia Umana-Diaz, Lucie Bonnet-Madin, Xavier Carnec, Jean-Yves Tinevez, Constance Delaugerre, Olivier Schwartz, Philippe Roingeard, Nolwenn Jouvenet, Clarisse Berlioz-Torrent, Laurent Meertens, Ali Amara   +16 more
doaj   +1 more source

Dengue virus neutralizing antibody levels associated with protection from infection in thai cluster studies. [PDF]

PLoS Neglected Tropical Diseases, 2014
Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection.Data ...
Darunee Buddhari, Jared Aldstadt, Timothy P Endy, Anon Srikiatkhachorn, Butsaya Thaisomboonsuk, Chonticha Klungthong, Ananda Nisalak, Benjawan Khuntirat, Richard G Jarman, Stefan Fernandez, Stephen J Thomas, Thomas W Scott, Alan L Rothman, In-Kyu Yoon   +13 more
doaj   +1 more source

Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability

Animal Models and Experimental Medicine, EarlyView.
Optimized dengue fever animal model: IFNAR−/− BALB/c mice with intraperitoneal injection. Background screening: Between IFNAR−/− (BALB/c, C57BL/6) and AG129 mice, IFNAR−/−BALB/c exhibited the most severe symptoms: (1) highest weight loss and clinical scores; (2) peak viremia (5.44 log10 RNA copies/mL, day 4); (3) significant organ damage (liver/brain ...
Dan Liao, Ming Zhong, Wenjiang Zheng, Zhendong Guo, Ye Zhou, Qiuhong Li, Lijuan Qiu, Liangwen Yu, Haishan Long, Geng Li   +9 more
wiley   +1 more source

Phylogeographic analysis of dengue virus serotype 1 and cosmopolitan serotype 2 in Africa

International Journal of Infectious Diseases, 2023
Objectives: The origin and spread of dengue virus (DENV) circulating in Africa remain poorly characterized, with African sequences representing
Philippe Selhorst, Sebastian Lequime, Gytis Dudas, Sam Proesmans, Pascal Lutumba, Freddy Katshongo, Kadrie Ramadan, Isabel Micalessi, Steve Ahuka-Mundeke, Veerle Vanlerberghe, Marjan Van Esbroeck, Kevin K. Ariën   +11 more
doaj   +1 more source

A clustered regularly interspaced palindromic repeat‐Cas12a‐based assay for rapid dengue virus monitoring in mosquito and clinical samples facilitating global collaborative surveillance and risk assessment to block dengue spreading

Interdisciplinary Medicine, EarlyView.
The RAA‐Cas12a assay outperforms real‐time PCR in sensitivity (92.3%) while matching its specificity (100%) for dengue virus detection in clinical samples. It effectively identifies DENV in mosquitoes, with field data correlating to local outbreaks. This rapid, simple, and precise method serves as an early warning tool for dengue management.
Xiang Guo, Minling Hu, Ying Lu, Xiaohua Liu, Haiyang Chen, Xiaoqing Zhang, Liu Ge, Ziyao Li, Yuji Wang, Qing He, Shu Zeng, Wenwen Ren, Lingzhai Zhao, Zhiqiang Peng, Wushen Chen, Chunmei Wang, Qingming Kong, Shaohong Lu, Fuchun Zhang, Lei Luo, Hua Li, Xiao‐Guang Chen, Xiaohong Zhou   +22 more
wiley   +1 more source

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, EarlyView.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

The Role of Heterotypic DENV-specific CD8+T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection

EBioMedicine, 2017
Dengue is the most prevalent arthropod-borne viral disease worldwide and is caused by the four dengue virus serotypes (DENV-1-4). Sequential heterologous DENV infections can be associated with severe disease manifestations.
Laura B. Talarico, Juan P. Batalle, Alana B. Byrne, Jorge M. Brahamian, Adrián Ferretti, Ayelén G. García, Aldana Mauri, Carla Simonetto, Diego R. Hijano, Andrea Lawrence, Patricio L. Acosta, Mauricio T. Caballero, Yésica Paredes Rojas, Lorena I. Ibañez, Guillermina A. Melendi, Félix A. Rey, Elsa B. Damonte, Eva Harris, Fernando P. Polack   +18 more
doaj   +1 more source

Standardization of quantitative dengue virus nonstructural-1 ELISA for quantitation of dengue virus nonstructural-1 levels in human serum

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Introduction: Dengue virus (DENV) infection is a significant global public health problem, caused by four antigenically distinct serotypes of DENV, namely, DENV-1, DENV-2, DENV-3, and DENV-4.
Puneet Bhatt, Santhosha Devadiga, Muralidhar Varma, Chiranjay Mukhopadhyay   +3 more
doaj   +1 more source