Results 181 to 190 of about 192,494 (228)
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Biochemistry (Moscow), 2004
Although mammalian deoxyribonucleases were discovered more than 60 years ago, interest in these enzymes is not weakening. During the last decade, intensive studies of human DNases culminated in discovery of several novel enzymes exhibiting DNase activity. These include an unusual DNase, lactoferrin.
A G, Baranovskii +2 more
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Although mammalian deoxyribonucleases were discovered more than 60 years ago, interest in these enzymes is not weakening. During the last decade, intensive studies of human DNases culminated in discovery of several novel enzymes exhibiting DNase activity. These include an unusual DNase, lactoferrin.
A G, Baranovskii +2 more
openaire +2 more sources
European Journal of Medicinal Chemistry, 2014
Deoxyribonucleases (DNases) are a class of enzymes able to catalyze DNA hydrolysis. DNases play important roles in cell function, while DNase inhibitors control or modify their activities. This review focuses on DNase inhibitors. Some DNase inhibitors have been isolated from various natural sources, such as humans, animals (beef, calf, rabbit and rat),
Ana, Kolarevic +3 more
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Deoxyribonucleases (DNases) are a class of enzymes able to catalyze DNA hydrolysis. DNases play important roles in cell function, while DNase inhibitors control or modify their activities. This review focuses on DNase inhibitors. Some DNase inhibitors have been isolated from various natural sources, such as humans, animals (beef, calf, rabbit and rat),
Ana, Kolarevic +3 more
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Deoxyribonuclease immobilized on the erythrocytes
Experientia, 1981Bovine pancreatic deoxyribonuclease (DNase I) was immobilized on human erythrocytes with several procedures. DNase immobilized on the erythrocytes by chromic chloride showed DNase activity in vitro. Other binding procedures inhibit the immobilized DNase activity.
T, Kitao, Y, Kitao, K, Hattori
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Chromosome Breakage by Deoxyribonuclease
Nature, 1970THE possibility that endogenous deoxyribonuclease might play a part in inducing chromatid breakage was suggested by our experiments describing a high incidence of chromosome breaks and rearrangements in human diploid cell strains after selective damage to lysosomes1.
G R, Paton, A C, Allison
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The Role of Tryptophan in the Inactivation of Deoxyribonuclease
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1967SummaryDeoxyribonuclease I (DNase I) has been irradiated in dilute solution in aerobic and anaerobic conditions, using α- and γ-radiations with a view to investigating an earlier suggestion that radiation-induced inactivation was caused by the destruction of a tryptophan residue at the active site.The relationship between the loss of tryptophan, and ...
R C, Armstrong, A, Charlesby
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Deoxyribonucleases in Human Parotid Saliva
Enzyme, 2017Deoxyribonuclease (EC 3.1.4.5, EC 3.1.4.6) activities in human parotid saliva were examined by microdisc electrophoresis. Three fractions, differing in their electrophoretic mobility and in their optimal incubation conditions, were characterized. The various enzyme activities were tested at pH 5.0 in 100 mmol * 1^-1 Na-acetate buffer or at pH 7.4 in ...
E J, Zöllner +3 more
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Role of Deoxyribonuclease in Cancer Chemotherapy
Journal of Pharmaceutical Sciences, 1974It has been postulated that the lysosomal enzyme deoxyribonuclease is responsible for nicks in both strands of deoxyribonucleic acid so that alkylating agents can cross-link the nucleotides of the two strands. Administration of an alkylating agent, p-di(2-chloroethyl)amino-L-phenylamine, to CF1 mice results in elevated activities of free ...
I H, Hall, K S, Ishaq, C, Piantadosi
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Digestion of chromatin with deoxyribonuclease II
Molecular Biology Reports, 1977The action of DNAse II on DNA in chromatin was studied. The formation of acid-soluble products followed a two-phase kinetic curve. At the end of the first more rapid phase about 25% of DNA was degraded. Early in the degradation process DNA was converted into double stranded fragments, whose sizes were multiples of about 180 base pairs.
M, Yaneva, G, Dessev
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The Effect of Radiation on Tissue Deoxyribonuclease
Radiation Research, 1959ln the radiosensitive spleen, bone marrow, and thymus, total-body, lethal x irradiation of the mouse produces a rapid increase in acid deoxyribonuclease activity per average cell. At the same time, a decrease in nn inhibitor of serum alkaline deoxyribonuclease is demonstrable in spleen homogenates. Post-irradiation infusion of homologous bone marrow is
N B, KURNICK, B W, MASSEY, G, SANDEEN
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