Results 1 to 10 of about 3,251,205 (352)

Immunoregulatory properties of cell free DNA [PDF]

Cellular and Molecular Life Sciences
Cell free DNA (cfDNA) is detectable at low concentrations in the plasma of healthy subjects and at high concentrations in disorders characterized by a high rate of necrotic events, such as tumors and vasculitis, leading to the release of necrotic DNA ...
Francesca Ferrera, Tiziana Altosole, Samuele Tardito, Giuseppina Astone, Cinzia Bernardi, Alessia Parodi, Chiara Marini, Giuseppina Conteduca, Elena Cichero, Annalisa Salis, Leonardo Arpesella, Laura Camporesi, Andrea Lagazio, Valentina Rigo, Andrea Pigozzo, Gianluca Damonte, Paola Fossa, Daniela Fenoglio, Raffaele De Palma, Giorgio Inghirami, Gilberto Filaci   +20 more
doaj   +4 more sources

Phenotypes from cell-free DNA [PDF]

Open Biology, 2020
Cell-free DNA (cfDNA) has the potential to enable non-invasive detection of disease states and progression. Beyond its sequence, cfDNA also represents the nucleosomal landscape of cell(s)-of-origin and captures the dynamics of the epigenome.
Alexis Zukowski, Satyanarayan Rao, Srinivas Ramachandran   +2 more
doaj   +3 more sources

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Nature Communications, 2017
Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole ...
Viktor A. Adalsteinsson, Gavin Ha, Samuel S. Freeman, Atish D. Choudhury, Daniel G. Stover, Heather A. Parsons, Gregory Gydush, Sarah C. Reed, Denisse Rotem, Justin Rhoades, Denis Loginov, Dimitri Livitz, Daniel Rosebrock, Ignaty Leshchiner, Jaegil Kim, Chip Stewart, Mara Rosenberg, Joshua M. Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, Paz Polak, Max Lloyd, Sairah Mahmud, Karla Helvie, Margaret S. Merrill, Rebecca A. Santiago, Edward P. O’Connor, Seong H. Jeong, Rachel Leeson, Rachel M. Barry, Joseph F. Kramkowski, Zhenwei Zhang, Laura Polacek, Jens G. Lohr, Molly Schleicher, Emily Lipscomb, Andrea Saltzman, Nelly M. Oliver, Lori Marini, Adrienne G. Waks, Lauren C. Harshman, Sara M. Tolaney, Eliezer M. Van Allen, Eric P. Winer, Nancy U. Lin, Mari Nakabayashi, Mary-Ellen Taplin, Cory M. Johannessen, Levi A. Garraway, Todd R. Golub, Jesse S. Boehm, Nikhil Wagle, Gad Getz, J. Christopher Love, Matthew Meyerson   +56 more
doaj   +2 more sources

Comparison of methods for the isolation of cell-free DNA from cell culture supernatant

Tumor Biology, 2020
In vitro characterization of cell-free DNA using two-dimensional cell culture models is emerging as an important step toward an improved understanding of the physical and biological characteristics of cell-free DNA in human biology.
Abel Jacobus Bronkhorst, Vida Ungerer, Stefan Holdenrieder   +2 more
doaj   +2 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders [PDF]

Advanced Science
Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs. Cell‐free DNA (cfDNA) is not only a biomarker for various inflammatory diseases, but also a driver in innate immune responses, offering ...
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
doaj   +2 more sources

Life and death of circulating cell-free DNA

Cancer Biology and Therapy, 2019
Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of biomarkers for minimally invasive serial monitoring of treatment responses in cancer management.
Albert Grinshpun
exaly   +2 more sources

Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes

Nature Medicine, 2020
Improving early cancer detection has the potential to substantially reduce cancer-related mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP–seq) is a highly sensitive assay capable of detecting early-stage ...
Shu Yi Shen, Gwo-Shu Mary Lee, Dror Michaelson   +2 more
exaly   +2 more sources

The emerging role of cell-free DNA as a molecular marker for cancer management

Biomolecular Detection and Quantification, 2019
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and monitoring.
Vida Ungerer, Abel Bronkhorst
exaly   +2 more sources

Cell-Free DNA Fragmentomics in Liquid Biopsy

Diagnostics, 2022
Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma cfDNA consists of a mixture of molecules originating from various bodily tissues.
Spencer C. Ding, Y.M. Dennis Lo
doaj   +2 more sources

Cell-free fetal DNA and cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy. [PDF]

PLoS ONE, 2013
Cell-free fetal DNA and cell-free total DNA in maternal circulation have been proposed as potential markers for noninvasive monitoring of the placental condition during the pregnancy. However, the correlation of and change in cell-free fetal DNA and cell-
Ji Hyae Lim, Min Hyoung Kim, You Jung Han, Da Eun Lee, So Yeon Park, Jung Yeol Han, Moon Young Kim, Hyun Mee Ryu   +7 more
doaj   +1 more source