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Phenotypes from cell-free DNA [PDF]

Open Biology, 2020
Cell-free DNA (cfDNA) has the potential to enable non-invasive detection of disease states and progression. Beyond its sequence, cfDNA also represents the nucleosomal landscape of cell(s)-of-origin and captures the dynamics of the epigenome.
Alexis Zukowski, Satyanarayan Rao, Srinivas Ramachandran   +2 more
doaj   +3 more sources

Immunoregulatory properties of cell free DNA. [PDF]

Cell Mol Life Sci
Cell free DNA (cfDNA) is detectable at low concentrations in the plasma of healthy subjects and at high concentrations in disorders characterized by a high rate of necrotic events, such as tumors and vasculitis, leading to the release of necrotic DNA ...
Ferrera F, Altosole T, Tardito S, Astone G, Bernardi C, Parodi A, Marini C, Conteduca G, Cichero E, Salis A, Arpesella L, Camporesi L, Lagazio A, Rigo V, Pigozzo A, Damonte G, Fossa P, Fenoglio D, De Palma R, Inghirami G, Filaci G.   +20 more
europepmc   +2 more sources

Cell-free DNA and outcome in sepsis. [PDF]

Critical Care, 2012
Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition
Cecconi, M, Rhodes, A
core   +5 more sources

Cell-Free DNA-Based Theranostics for Inflammatory Disorders. [PDF]

Adv Sci (Weinh)
Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs. Cell‐free DNA (cfDNA) is not only a biomarker for various inflammatory diseases, but also a driver in innate immune responses, offering ...
Li J, Wang Y, Fan X, Xu M, Li J, Tan W, Zhang J, Li H.   +7 more
europepmc   +2 more sources

Brain-derived cell-free DNA

Neural Regeneration Research, 2022
Dean Southwood, Sanyukta Singh, Zac Chatterton   +2 more
doaj   +3 more sources

Cell-free circulating tumor DNA in cancer [PDF]

Chinese Journal of Cancer, 2016
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in
Zhen Qin, Vladimir A. Ljubimov, Cuiqi Zhou, Yunguang Tong, Jimin Liang   +4 more
doaj   +5 more sources

Circulating cell-free DNA biomarkers

APIK Journal of Internal Medicine, 2021
Jose Rafael Villarreal Escorcia
doaj   +2 more sources

Cell-free DNA screening in twin pregnancies [PDF]

Obstetrics & Gynecology Science
Cell-free DNA (cfDNA) screening for fetal aneuploidies is clinically available and exhibits better performance than conventional serum screening tests. However, data on the clinical performance of cfDNA screening in twin pregnancies are limited.
Hye Yeon Boo, You Jung Han
doaj   +3 more sources

Cell-free (RNA) and cell-associated (DNA) HIV-1 and postnatal transmission through breastfeeding [PDF]

, 2012
<p>Introduction - Transmission through breastfeeding remains important for mother-to-child transmission (MTCT) in resource-limited settings. We quantify the relationship between cell-free (RNA) and cell-associated (DNA) shedding of HIV-1 virus in ...
A Antinori, A Ayouba, A Gupta, AJ Ruff, AS Goldman, BA Richardson, C Bennetto-Hood, C Kilewo, CL Townsend, Claire Thorne, CM Rousseau, CM Rousseau, CS Chasela, D Chege, D Neveu, D Valea, DA Lehman, ER Cooper, F Rouet, FA Mmiro, G John-Stewart, GC John, HM Coovadia, I de Vincenzi, IN Koulinska, JA Slyker, James Ndirangu, JF Willumsen, Johannes Viljoen, K Pillay, K Semrau, L Houzet, LA Guay, Landon Myer, Marie-Louise Newell, MH Chung, MH Chung, MH Chung, MK Ghosh, ML Newell, P Becquart, P Lewis, P Van de Perre, P Van de Perre, Philippe Van de Perre, R Bland, RD Semba, RL Shapiro, RL Shapiro, RM Bland, Ruth M. Bland, RW Nduati, S Cassol, S Gantt, S Tasker, Siva Danaviah, Study European Collaborative, Study European Collaborative, TK Thomas, W Khamduang   +59 more
core   +16 more sources

Cell-Free DNA in Rheumatoid Arthritis [PDF]

International Journal of Molecular Sciences, 2021
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is associated with various pathological conditions. Recently, multiple aspects of cfDNA have been assessed, including cfDNA levels, integrity, methylation, and mutations.
Hashimoto, Teppei, Yoshida, Kohsuke, Hashiramoto, Akira, Matsui, Kiyoshi   +3 more
openaire   +2 more sources