Results 1 to 10 of about 265,282 (276)

Increased levels of circulating cell‐free double‐stranded nucleic acids in the plasma of glioblastoma patients

Journal of Extracellular Biology
Circulating cell‐free nucleic acids are considered a promising source of biomarkers for diseases and cancer. Liquid biopsy biomarkers for brain tumours represent a major, still unmet, clinical need.
Elisabeth Rackles, Elena Zaccheroni, Patricia Hernandez Lopez, Stefania Faletti, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci, Juan M Falcon‐Perez   +7 more
doaj   +2 more sources

Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria

Pharmaceuticals, 2019
Antibiotic resistance is a growing public health concern. Because only a few novel classes of antibiotics have been developed in the last 40 years, such as the class of oxazolidinones, new antibacterial strategies are urgently needed (Coates, A.R. et al.,
Federico Perche, Tony Le Gall, Tristan Montier, Chantal Pichon, Jean-Marc Malinge   +4 more
doaj   +1 more source

Cancer type classification using plasma cell-free RNAs derived from human and microbes

eLife, 2022
The utility of cell-free nucleic acids in monitoring cancer has been recognized by both scientists and clinicians. In addition to human transcripts, a fraction of cell-free nucleic acids in human plasma were proven to be derived from microbes and ...
Shanwen Chen, Yunfan Jin, Siqi Wang, Shaozhen Xing, Yingchao Wu, Yuhuan Tao, Yongchen Ma, Shuai Zuo, Xiaofan Liu, Yichen Hu, Hongyan Chen, Yuandeng Luo, Feng Xia, Chuanming Xie, Jianhua Yin, Xin Wang, Zhihua Liu, Ning Zhang, Zhenjiang Zech Xu, Zhi John Lu, Pengyuan Wang   +20 more
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Diagnostic potential of cell-free fetal nucleic acids in predicting pregnancy complications: A systematic review and meta-analysis on trisomy, pre-eclampsia, and gestational diabetes

International Journal of Reproductive BioMedicine
Background: Recent studies reveal an association between increased cell-free fetal (cff) nucleic acid in maternal blood and pregnancy challenges like loss, pre-eclampsia, growth restriction, and preterm labor.
Jiut Ram Keshari, Pritam Prakash, Seema Rani Sinha, Prem Prakash, Kirti Rani, Tarique Aziz, Shaily Shilpa   +6 more
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Opportunities and challenges of circulating biomarkers in neuroblastoma [PDF]

Open Biology, 2019
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on analysis
Ricky M. Trigg, Jacqui A. Shaw, Suzanne D. Turner   +2 more
doaj   +1 more source

Recent advances in cancer-associated circulating cell-free nucleic acids

Zhongguo aizheng zazhi, 2014
Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly ...
邢星, 刘勇, 孙勇, 周鑫, 胡超苏   +4 more
doaj  

Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders

Frontiers in Physiology, 2018
Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common cause of chronic liver pathology, which prevalence strongly correlates with the increasing incidence of diabetes, obesity and metabolic syndrome in the general population.
Andrey Turchinovich, Andrey Turchinovich, Ancha Baranova, Ancha Baranova, Ancha Baranova, Oksana Drapkina, Alexander Tonevitsky, Alexander Tonevitsky, Alexander Tonevitsky   +8 more
doaj   +1 more source

Denatured mammalian protein mixtures exhibit unusually high solubility in nucleic acid-free pure water. [PDF]

PLoS ONE, 2014
Preventing protein aggregation is a major goal of biotechnology. Since protein aggregates are mainly comprised of unfolded proteins, protecting against denaturation is likely to assist solubility in an aqueous medium.
Junichiro Futami, Haruna Fujiyama, Rie Kinoshita, Hidenori Nonomura, Tomoko Honjo, Hiroko Tada, Hirokazu Matsushita, Yoshito Abe, Kazuhiro Kakimi   +8 more
doaj   +1 more source

Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles

Nature Communications
Real-time and continuous monitoring of nucleic acid biomarkers with wearable devices holds potential for personal health management, especially in the context of pandemic surveillance or intensive care unit disease.
Bin Yang, Haonan Wang, Jilie Kong, Xueen Fang   +3 more
doaj   +1 more source

Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility

Basic and Clinical Andrology, 2017
Résumé L’infertilité masculine est un problème qui touche de nombreux couples. Cependant, aujourd’hui les mécanismes moléculaires et les causes de l’infertilité masculine idiopathique ne sont pas élucidés.
Anne Boissière, Anna Gala, Alice Ferrières-Hoa, Tiffany Mullet, Solenne Baillet, Amaël Petiton, Antoine Torre, Samir Hamamah   +7 more
doaj   +1 more source