Circulating Cell-Free Nucleic Acids as Epigenetic Biomarkers in Precision Medicine [PDF]
Frontiers in Genetics, 2020 The circulating cell-free nucleic acids (ccfNAs) are a mixture of single- or double-stranded nucleic acids, released into the blood plasma/serum by different tissues via apoptosis, necrosis, and secretions. Under healthy conditions, ccfNAs originate from
Beenish Rahat +4 more
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Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer [PDF]
Biomedicines, 2023 A lack of reliable early diagnostic tools represents a major challenge in the management of pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced stage.
Anelis Maria Marin +5 more
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Circulating cell-free nucleic acids of plasma in human aging, healthy aging and longevity: current state of knowledge [PDF]
Frontiers in Genetics, 2023 Circulating cell-free nucleic acids (ccfNAs) of plasma are a remarkable source of genetic, epigenetic and transcriptomic materials originating from different cells, tissues and organs of an individual.
Nicolas P. Tessier +4 more
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Integrated analysis of circulating cell free nucleic acids for cancer genotyping and immune phenotyping of tumor microenvironment [PDF]
Frontiers in Genetics, 2023 The circulating cell-free nucleic acids (ccfNAs) consist of a heterogenous cocktail of both single (ssNA) and double-stranded (dsNA) nucleic acids. These ccfNAs are secreted into the blood circulation by both healthy and malignant cells via various ...
Muskan Chaddha +3 more
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Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application. [PDF]
Int J Mol Sci, 2020 Liquid biopsy recently became a very promising diagnostic method that has several advantages over conventional invasive methods. Liquid biopsy may serve as a source of several important biomarkers including cell-free nucleic acids (cf-NAs). Cf-DNA is widely used in prenatal testing in order to characterize fetal genetic disorders.
Szilágyi M +8 more
europepmc +5 more sources
An Overview of Circulating Cell-Free Nucleic Acids in Diagnosis and Prognosis of Triple-Negative Breast Cancer. [PDF]
Int J Mol Sci, 2023 Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer due to its molecular heterogeneity and poor clinical outcomes. Analysis of circulating cell-free tumor nucleic acids (ctNAs) can improve our understanding of TNBC and provide efficient and non-invasive clinical biomarkers that may be representative of tumor heterogeneity. In
Tierno D +4 more
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Integrative Multiparametric Analysis of Circulating Cell-Free Nucleic Acids of Plasma in Healthy Individuals During Aging. [PDF]
Aging CellABSTRACTPlasma circulating cell‐free nucleic acids (ccfNAs) provide an exceptional source of information about an individual's health, yet their biology in healthy individuals during aging remains poorly understood. Here, we present the first integrative multiparametric analysis of the major types of plasma ccfNAs, including nuclear (ccfnDNA) and ...
Tessier NP +10 more
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Journal of Extracellular BiologyCirculating cell‐free nucleic acids are considered a promising source of biomarkers for diseases and cancer. Liquid biopsy biomarkers for brain tumours represent a major, still unmet, clinical need.
Elisabeth Rackles +7 more
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Bioanalytical Applications of Graphene Quantum Dots for Circulating Cell-Free Nucleic Acids: A Review. [PDF]
ACS Omega, 2022 Graphene quantum dots (GQDs) are carbonaceous nanodots that are natural crystalline semiconductors and range from 1 to 20 nm. The broad range of applications for GQDs is based on their unique physical and chemical properties. Compared to inorganic quantum dots, GQDs possess numerous advantages, including formidable biocompatibility, low intrinsic ...
Ratre P +7 more
europepmc +3 more sources
Circulating Cell-free Tumor Nucleic Acids in Gastric Cancer [PDF]
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2018 Gastric cancer is still the leading cause of cancer deaths, especially in Asian countries. Recently, many studies have analyzed cell-free nucleic acids (cfNAs) circulating in the blood, for the early diagnosis of cancer and monitoring its progression ...
Hyun-Ji Lee, Sun Min Lee
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