Results 1 to 10 of about 1,066,214 (229)

Cell-free RNA signatures predict Alzheimer's disease. [PDF]

iScience, 2023
Summary: There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer’s disease that can be applied to a population level.
Cisterna-García A, Beric A, Ali M, Pardo JA, Chen HH, Fernandez MV, Norton J, Gentsch J, Bergmann K, Budde J, Perlmutter JS, Morris JC, Cruchaga C, Botia JA, Ibanez L.   +14 more
europepmc   +5 more sources

Combining cell-free RNA with cell-free DNA in liquid biopsy for hematologic and solid tumors. [PDF]

Heliyon, 2023
Current use of liquid biopsy is based on cell-free DNA (cfDNA) and the evaluation of mutations or methylation pattern. However, expressed RNA can capture mutations, changes in expression levels due to methylation, and provide information on cell of ...
Albitar M, Zhang H, Charifa A, Ip A, Ma W, McCloskey J, Donato M, Siegel D, Waintraub S, Gutierrez M, Pecora A, Goy A.   +11 more
europepmc   +4 more sources

Diurnal stability of cell-free DNA and cell-free RNA in human plasma samples [PDF]

Scientific Reports, 2020
Many emerging technologies are reliant on circulating cell-free DNA (cfDNA) and cell-free RNA (cfRNA) applications in the clinic. However, the impact of diurnal cycles or daily meals on circulating analytes are poorly understood and may be confounding ...
Josiah T. Wagner, Hyun Ji Kim, Katie C. Johnson-Camacho, Taylor Kelley, Laura F. Newell, Paul T. Spellman, Thuy T. M. Ngo   +6 more
doaj   +3 more sources

Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications. [PDF]

Clin Chem
Abstract Background There is increasing interest in the use of circulating cell-free RNA (cfRNA) in plasma as an analyte for diagnosing and monitoring disease. While it is known that cfRNA can also be isolated from urine, the diagnostic potential of urine cfRNA, particularly relative to plasma cfRNA ...
Mzava O, Agun GF, Loy CJ, Gonzalez-Bocco IH, Djomnang Kounatse LA, Bliss A, Wells SL, Lenz J, Belcher E, Chen K, Koo S, Baden LR, Chu T, Cheng MP, Ritz J, Gupta S, De Vlaminck I.   +16 more
europepmc   +3 more sources

Improved cell-free RNA and protein synthesis system. [PDF]

PLoS ONE, 2014
Cell-free RNA and protein synthesis (CFPS) is becoming increasingly used for protein production as yields increase and costs decrease. Advances in reconstituted CFPS systems such as the Protein synthesis Using Recombinant Elements (PURE) system offer new
Jun Li, Liangcai Gu, John Aach, George M Church   +3 more
doaj   +6 more sources

An ultrasensitive method for detection of cell-free RNA. [PDF]

Nature
Sensitive methods for detection of cell-free RNA (cfRNA) could facilitate non-invasive gene expression profiling and monitoring of diseases1-6. Here we describe RARE-seq (random priming and affinity capture of cfRNA fragments for enrichment analysis by sequencing), a method optimized for cfRNA analysis.
Nesselbush MC, Luca BA, Jeon YJ, Jabara I, Meador CB, Garofalo A, Binkley MS, Hui AB, van 't Erve I, Xu N, Shi WY, Liu KJ, Sugio T, Kastelowitz N, Hamilton EG, Liu CL, Olsen M, Bonilla RF, Wang YP, Jiang A, Lau B, Eichholz J, Banwait M, Schroers-Martin J, Boegeholz J, King DA, Luikart H, Esfahani MS, Mehrmohamadi M, Stehr H, Raclin T, Tibshirani R, Khush K, Srinivas S, Yu H, Rogers AJ, Nair VS, Isbell JM, Li BT, Piotrowska Z, Sequist LV, Hata AN, Neal JW, Wakelee HA, Gentles AJ, Alizadeh AA, Diehn M.   +46 more
europepmc   +3 more sources

Early prediction of preeclampsia in pregnancy with cell-free RNA. [PDF]

Nature, 2022
Abstract Liquid biopsies that measure circulating cell-free RNA (cfRNA) offer an opportunity to study the development of pregnancy-related complications in a non-invasive manner and to bridge gaps in clinical care 1–4 .
Moufarrej MN, Vorperian SK, Wong RJ, Campos AA, Quaintance CC, Sit RV, Tan M, Detweiler AM, Mekonen H, Neff NF, Baruch-Gravett C, Litch JA, Druzin ML, Winn VD, Shaw GM, Stevenson DK, Quake SR.   +16 more
europepmc   +4 more sources

Minimal correlation but complementary diagnostic utility for plasma cell-free RNA and proteins. [PDF]

Commun Med (Lond)
Background Proteins and RNA circulate in plasma and can offer insights into human physiology. Yet, despite their clinical importance, direct comparisons between these analytes remain unexplored. Methods: Here, we measure and compare plasma cell-free RNA (
Bliss A, Loy CJ, Kim J, Shimizu C, Lenz JS, Belcher E, Tremoulet AH, Burns JC, De Vlaminck I.   +8 more
europepmc   +2 more sources

Molecular characterization of Kawasaki disease subgroups using cell-free RNA profiling. [PDF]

Sci Rep
Kawasaki disease is a pediatric vasculitis and the leading cause of acquired heart disease in children. The heterogeneous clinical presentation of Kawasaki disease complicates diagnosis and treatment, highlighting the need for molecular signatures to ...
Loy CJ, Wang H, Kim J, Shimizu C, Lenz J, Belcher E, Tremoulet AH, Burns JC, De Vlaminck I.   +8 more
europepmc   +2 more sources

Noninvasive prediction of fetal growth restriction using maternal plasma cell-free RNA: a case-control study. [PDF]

BMC Pregnancy Childbirth
Background Fetal growth restriction (FGR) is a significant concern due to its potential adverse outcomes for both mothers and infants. Cell-free RNA in maternal plasma has been suggested as a potential biomarker for pregnancy complications, but its ...
Huang Y, Wang R, Shen L, Kong L, Chen P, Wang Z, Li Z.   +6 more
europepmc   +2 more sources