Results 11 to 20 of about 1,066,214 (229)

Diurnal Variations of Human Circulating Cell-Free Micro-RNA. [PDF]

PLoS ONE, 2016
A 24-hour light and dark cycle-dependent rhythmicity pervades physiological processes in virtually all living organisms including humans. These regular oscillations are caused by external cues to endogenous, independent biological time-keeping systems ...
Niels H H Heegaard, Anting Liu Carlsen, Berit Lilje, Kim Lee Ng, Mette E Rønne, Henrik L Jørgensen, Henriette Sennels, Jan Fahrenkrug   +7 more
doaj   +5 more sources

Plasma cell-free RNA signatures of inflammatory syndromes in children. [PDF]

Proc Natl Acad Sci U S A
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell-free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization ...
Loy CJ, Servellita V, Sotomayor-Gonzalez A, Bliss A, Lenz JS, Belcher E, Suslovic W, Nguyen J, Williams ME, Oseguera M, Gardiner MA, P.E.M.K.D.R.G., C.H.A.R.M.S. the Study Group, Choi JH, Hsiao HM, Wang H, Kim J, Shimizu C, Tremoulet AH, Delaney M, DeBiasi RL, Rostad CA, Burns JC, Chiu CY, De Vlaminck I.   +24 more
europepmc   +5 more sources

Diagnostic and Therapeutic Potential of Circulating-Free DNA and Cell-Free RNA in Cancer Management. [PDF]

Biomedicines, 2022
Over time, molecular biology and genomics techniques have been developed to speed up the early diagnosis and clinical management of cancer. These therapies are often most effective when administered to the subset of malignancies harboring the target ...
Hassan S, Shehzad A, Khan SA, Miran W, Khan S, Lee YS.   +5 more
europepmc   +2 more sources

Decoding bioactive signals of the RNA secretome: the cell-free messenger RNA catalogue

Expert Reviews in Molecular Medicine
Despite gene-expression profiling being one of the most common methods to evaluate molecular dysregulation in tissues, the utilization of cell-free messenger RNA (cf-mRNA) as a blood-based non-invasive biomarker analyte has been limited compared to other
Rhys E. De Sota, Stephen R. Quake, John J. Sninsky, Shusuke Toden   +3 more
doaj   +3 more sources

Utilizing nullomers in cell-free RNA for early cancer detection. [PDF]

Cancer Gene Ther
Abstract Early detection of cancer can significantly improve patient outcomes; however, sensitive and highly specific biomarkers for cancer detection are currently missing. Nullomers are the shortest sequences that are absent from the human genome but can emerge due to somatic mutations in cancer.
Montgomery A, Tsiatsianis GC, Mouratidis I, Chan CSY, Athanasiou M, Papanastasiou AD, Kantere V, Syrigos N, Vathiotis I, Syrigos K, Yee NS, Georgakopoulos-Soares I.   +11 more
europepmc   +4 more sources

Depletion-assisted multiplexed cell-free RNA sequencing reveals distinct human and microbial signatures in plasma versus extracellular vesicles. [PDF]

Clin Transl Med
Background Cell‐free long RNAs in human plasma and extracellular vesicles (EVs) have shown promise as biomarkers in liquid biopsy, despite their fragmented nature.
Wang H, Zhan Q, Ning M, Guo H, Wang Q, Zhao J, Bao P, Xing S, Chen S, Zuo S, Xia X, Li M, Wang P, Lu ZJ.   +13 more
europepmc   +2 more sources

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma [PDF]

ExRNA, 2023
Background: Minimally invasive liquid biopsies are becoming increasingly important in the diagnosis and treatment follow-up of cancer patients, including children with neuroblastoma.
Jill Deleu, Hanne Van Droogenbroeck, Jasper Anckaert, Anneleen Decock, Jilke De Wilde, Kaat Durinck, Liselot M. Mus, Justine Nuytens, Muhammad Rishfi, Kathleen Schoofs, Frank Speleman, Maaike Van Trimpont, Kimberly Verniers, Nurten Yigit, Jo Vandesompele, Bram De Wilde, Tom Van Maerken   +16 more
doaj   +1 more source

The role of liquid biopsy in the diagnosis of glioblastoma progression

Сибирский онкологический журнал, 2022
Purpose: to summarize available data on the diagnostic value of various circulating biomarkers for the detection of glioblastoma recurrence.Material and Methods.
A. I. Ryabova, V. A. Novikov, E. L. Choynzonov, L. V. Spirina, N. V. Yunusova, A. A. Ponomareva, S. N. Tamkovich, O. V. Gribova   +7 more
doaj   +1 more source

Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes

Epigenetics, 2021
Although analysis of maternal plasma cell-free content has been employed for screening of genetic abnormalities within a pregnancy, limited attention has been paid to its use for the detection of adverse pregnancy outcomes (APOs) based on placental ...
Giorgia Del Vecchio, Qingjiao Li, Wenyuan Li, Shanthie Thamotharan, Anela Tosevska, Marco Morselli, Kyunghyun Sung, Carla Janzen, Xianghong Zhou, Matteo Pellegrini, Sherin U. Devaskar   +10 more
doaj   +1 more source

Cell-free RNA and fully convolutional dense network-based early preeclampsia prediction. [PDF]

Clin Transl Med, 2023
Zhao Z, Li B, Xiao X, Liu J, Zheng W.
europepmc   +2 more sources