Results 31 to 40 of about 44,285 (229)
Revista da Sociedade Brasileira de Medicina Tropical, 2020 Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers.
Iran Mendonça-da-Silva +8 more
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Assessment of cell-free DNA for early detection of ovarian cancer in women [PDF]
Journal of Bioscience and Applied Research, 2019 Objectives: To assess circulating cell-free DNA’s diagnostic potential in Egyptian women with ovarian cancer. Background: Ovarian cancer (OC), one of the most common cancers worldwide, is the most lethal form of gynecological cancer, but the early ...
Waleed Fathy +4 more
doaj +1 more source
Journal of Translational Medicine, 2020 During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalities.
Haiou Yang +3 more
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BMC Cancer, 2011 Background As cell-free circulating DNA exists predominantly as mono- and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of patients with benign and malignant
Kasimir-Bauer Sabine +6 more
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Current challenges and best practices for cell-free long RNA biomarker discovery
Biomarker Research, 2022 The analysis of biomarkers in biological fluids, also known as liquid biopsies, is seen with great potential to diagnose complex diseases such as cancer with a high sensitivity and minimal invasiveness. Although it can target any biomolecule, most liquid
Lluc Cabús +4 more
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Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19
JCI Insight, 2021 Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined ...
Davide Scozzi +20 more
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection
Frontiers in Medicine, 2020 Among women, breast cancer (BC) is not only the most common cancer worldwide but also the leading cause of cancer death. Only 5–10% of breast cancer cases are attributed to inherited mutations (BRCA1, BRCA2, and other breast cancer susceptibility genes).
Farah J. Nassar +4 more
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Clinical and Translational Discovery, 2022 Recent years have witnessed the development of scientific research and clinical trials of liquid biopsy in various diseases, especially cancers. Liquid biopsy refers to a procedure in which components, including circulating tumour cells (CTCs), cell‐free
Zhixian Chen, Judy Wai Ping Yam
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