Results 31 to 40 of about 265,282 (276)

Mechanisms of nucleic acid degradation and high hydrostatic pressure tolerance of a novel deep-sea wall-less bacterium

open access: yesmBio, 2023
Wall-less bacteria are broadly distributed in diverse habitats. They evolved from a common ancestor within the Firmicutes phylum through reductive evolution.
Rikuan Zheng   +4 more
doaj   +1 more source

Circulating cell-free nucleic acids as prognostic and therapy predictive tools for metastatic castrate-resistant prostate cancer. [PDF]

open access: yesWorld J Clin Oncol, 2020
Metastatic castrate-resistant prostate cancer remains a disease hard to cure, and for this reason predictive tools to monitor disease progression and therapy response are an urgent need.
Sobhani N   +4 more
europepmc   +2 more sources

Biochemical and clinical diagnostic aspects of circulating nucleic acids [PDF]

open access: yes, 2005
We investigated the size distribution of fetal DNA using a combination of agorose gel electrophoresis, Southern blot and real time PCR assay. Our results showed plasma DNA presents apoptotic characteristics and the cell free fetal DNA is generally ...
Li, Ying
core   +1 more source

Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

open access: yesCancer Biology & Medicine, 2016
Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals.
Jay Hocking   +3 more
doaj   +1 more source

Virus-Like Cytosolic and Cell-Free Oxidatively Damaged Nucleic Acids Likely Drive Inflammation, Synapse Degeneration, and Neuron Death in Alzheimer’s Disease

open access: yesJournal of Alzheimer's Disease Reports, 2023
Oxidative stress, inflammation, and amyloid-β are Alzheimer’s disease (AD) hallmarks that cause each other and other AD hallmarks. Most amyloid-β-lowering, antioxidant, anti-inflammatory, and antimicrobial AD clinical trials failed; none stopped or ...
Owen Davis Sanders
doaj   +1 more source

Exploring the Role of Cell-Free Nucleic Acids and Peritoneal Dialysis: A Narrative Review. [PDF]

open access: yesGenes (Basel)
Introduction: Cell-free nucleic acids (cf-NAs) represent a promising biomarker of various pathological and physiological conditions. Since its discovery in 1948, cf-NAs gained prognostic value in oncology, immunology, and other relevant fields. In peritoneal dialysis (PD), blood purification is performed by exposing the peritoneal membrane.
Morisi N   +6 more
europepmc   +4 more sources

The effect of prostaglandins on protein and nucleic acid synthesis in a cell-free system [PDF]

open access: yesLife Sciences, 1967
T6S EFFECT OF PROSTAGLAI~INS ON PROTEIN AND NDCLEIC ACID SYNTHESIS IN A CELL-FREE SYSTEM R. W. Ruddon* and J. M. Johnson Department of Pharmacology, The pniversity of Michigan Medical School Ann Arbor, Michigan (Received 20 February 1967 ; in final form 13 March 1967) THE prostaglandins are a family of hydroxy unsaturated C20 fatty acids which have ...
Ruddon, Raymond W., Johnson, J. M.
openaire   +3 more sources

Digital PCR-based evaluation of nucleic acid extraction kit performance for the co-purification of cell-free DNA and RNA

open access: yesHuman Genomics, 2022
Background Blood plasma, one of the most studied liquid biopsies, contains various molecules that have biomarker potential for cancer detection, including cell-free DNA (cfDNA) and cell-free RNA (cfRNA). As the vast majority of cell-free nucleic acids in
Jill Deleu   +10 more
doaj   +1 more source

Plasma GBP2 promoter methylation is associated with advanced stages in breast cancer [PDF]

open access: yesGenetics and Molecular Biology, 2020
Blood methylated cell-free DNA (cfDNA) as a minimally invasive cancer biomarker has great importance in cancer management. Guanylate binding protein 2 (GBP2) has been considered as a possible controlling factor in tumor development.
Farzaneh Rahvar   +2 more
doaj   +1 more source

Algorithms for Nucleic Acid Sequence Design [PDF]

open access: yes, 2010
Motivated by a growing field of research focused on programming function into biomolecules, we seek to decrease the cost of high-quality rational nucleic acid sequence design while increasing its versatility and availability.
Zadeh, Joseph N.
core   +1 more source

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