Results 1 to 10 of about 7,473,748 (355)
Science China Chemistry, 2020 Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things.
Bi-feng Yuan, Huang-Hao Yang, Juewen Liu
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Nature Reviews Methods Primers, 2022 There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented opportunity to overcome these drawbacks; owing to their tunability with ...
Bárbara B. Mendes +12 more
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The Nucleic Acid Knowledgebase: a new portal for 3D structural information about nucleic acids
Nucleic Acids Research, 2023 The Nucleic Acid Knowledgebase (nakb.org) is a new data resource, updated weekly, for experimentally determined 3D structures containing DNA and/or RNA nucleic acid polymers and their biological assemblies. NAKB indexes nucleic acid-containing structures
Catherine L. Lawson +4 more
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G-quadruplex formation at human DAT1 gene promoter: Effect of cytosine methylation
Biochemistry and Biophysics Reports, 2023 The dopamine transporter gene (DAT1), a recognized genetic risk factor for attention deficit hyperactivity disorder (ADHD) is principally responsible for the regulation of dopamine synaptic levels and serves as a key target in many psychostimulants drugs.
Nishu Nain +3 more
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Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications
Molecules, 2022 Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-
Cen Chen, Zhen Huang
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A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids.
Chemical Reviews, 2021 Click chemistry is an immensely powerful technique for the fast and efficient covalent conjugation of molecular entities. Its broad scope has positively impacted on multiple scientific disciplines, and its implementation within the nucleic acid field has
N. Z. Fantoni, A. El-Sagheer, T. Brown
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Chemical Science, 2021 Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) protein systems have transformed the field of genome editing and transcriptional modulation.
Wei Feng +11 more
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The smfBox is an open-source platform for single-molecule FRET
Nature Communications, 2020 Broad uptake of smFRET has been hindered by high instrument costs and a lack of open-source hardware and acquisition software. Here, the authors present the smfBox, a cost-effective open-source platform capable of measuring precise FRET efficiencies ...
Benjamin Ambrose +10 more
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Molecules, 2022 Oligonucleotide tools, as modulators of alternative splicing, have been extensively studied, giving a rise to new therapeutic approaches. In this article, we report detailed research on the optimization of bifunctional antisense oligonucleotides (BASOs),
Natalia Bartyś +2 more
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Pharmaceuticals, 2021 Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin.
Weronika Kotkowiak +2 more
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