Results 1 to 10 of about 516,976 (317)

G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives

Molecules, 2019
G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich oligonucleotides of DNA- or RNA-type. Depending on their chemical nature, loops length, and localization in the sequence or structure molecularity, G-quadruplexes are ...
Carolina Roxo, Weronika Kotkowiak, Anna Pasternak   +2 more
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Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes

Molecules, 2022
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen species (ROS) and the antioxidant defense system of the body.
Anju Singh, Ritushree Kukreti, Luciano Saso, Shrikant Kukreti   +3 more
doaj   +1 more source

Multiple nucleic acid cleavage modes in divergent type III CRISPR systems

, 2016
CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of transcription-dependent DNA targeting ...
Zhang, Jing, White, Malcolm Frederick, Tello, Agnes, Liu, Huanting, Graham, Shirley   +4 more
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Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe Ç

, 2011
Electron Paramagnetic Resonance (EPR) spectroscopy and fluorescence spectroscopy are complementary biophysical techniques used to examine the structure and dynamics of macromolecules.
Reginsson, Gunnar Widtfeldt, Olav Schiemann, Cekan, Pavol, Shelke, Sandip A., Adrian R. Ferré-D’Amaré, Gunnar W. Reginsson, Pavol Cekan, Edwards, Thomas E., Snorri Th. Sigurdsson, Schiemann, Olav, Sigurdsson, Snorri, Thomas E. Edwards, Ferre D'Amare, Adrian R., Sandip A. Shelke   +13 more
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Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation

Biomolecules
The selective regulation of gene expression at the RNA level represents a rapidly evolving field offering substantial clinical potential. This review examines the molecular mechanisms of intracellular enzymatic systems that utilize single-stranded ...
Daria A. Chiglintseva, Olga A. Patutina, Marina A. Zenkova   +2 more
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Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

Journal of Nucleic Acids, 2011
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations
Matthew J. Crawford, Srinivas Rapireddy, Raman Bahal, Iulia Sacui, Danith H. Ly   +4 more
doaj   +1 more source

Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery

, 2023
Yinshan Lin,1,2,* Xiaoling Guan,1,2,* Jianfen Su,1,2,* Sheng Chen,2 Xihua Fu,1 Xiaowei Xu,2 Xiaohua Deng,2 Jishuo Chang,2 Aiping Qin,2,* Ao Shen,2,* Lingmin Zhang1,2,* 1Pharmacy Department & Panyu Institute of Infectious Diseases,
Qin A, Shen A, Guan X, Fu X, Lin Y, Su J, Zhang L, Chen S, Xu X, Chang J, Deng X   +10 more
core  

Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor [PDF]

, 2020
With the central role of nucleic acids there is a need for development of fluorophores that facilitate the visualization of processes involving nucleic acids without perturbing their natural properties and behaviour.
Sandberg Wranne, Moa,, Gr\uf6tli, Morten, Wypijewska Del Nogal, Anna Wiktoria,, Grötli, Morten,, Pfeiffer, Pauline, El-Sagheer, Afaf,, Wypijewska Del Nogal, Anna Wiktoria, Sarangamath, Sangamesh, Bood, Mattias, Bood, Mattias,, Nilsson, Jesper, Sandberg Wranne, Moa, Wilhelmsson, Marcus, Brown, Tom, Brown, Tom,, Sundar Rajan, Vinoth, Pfeiffer, Pauline,, El-Sagheer, Afaf, Sarangamath, Sangamesh,, F\ufcchtbauer, Anders Foller, Dahlén, Anders,, Nilsson, Jesper,, Füchtbauer, Anders Foller,, Sundar Rajan, Vinoth,, Dahl\ue9n, Anders, Wilhelmsson, Marcus,   +25 more
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Nucleic acids and protein synthesis in cancer cell mitochondria. I. Nucleic acids in rat hepatoma mitochondria

, 1967
The contents of nucleic acids in rat liver and hepatoma mitochondria and the physico-chemical properties on DNA's isolated from these mitochondria were comparatively investigated. The results are briefly summarized as follows. 1.
Inaba, Kozo
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Time-Resolved Fluorescence Investigation of the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein: Influence of the Binding of Nucleic Acids

, 1999
Depending on the HIV-1 isolate, MN or BH10, the nucleocapsid protein, NCp7, corresponds to a 55- or 71-amino acid length product, respectively. The MN NCp7 contains a single Trp residue at position 37 in the distal zinc finger motif, and the BH10 NCp7 ...
Piemont, Etienne, Constance Vuilleumier, Etienne Piémont, Gerard, Dominique, Roques, Bernard P., Ababou, Abdessamad, Mely, Yves, Yves Mély, Bombarda, Elisa, Dominique Gérard, Bernard P. Roques, Abdessamad Ababou, Vuilleumier, Constance, Elisa Bombarda   +13 more
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