Results 31 to 40 of about 516,976 (317)
Molecules, 2021 RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz +7 more
doaj +1 more source
Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos
Frontiers in Bioengineering and Biotechnology, 2020 The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are ...
Seema Gupta +4 more
doaj +1 more source
Extracellular vesicles and their nucleic acids for biomarker discovery [PDF]
, 2018 Extracellular vesicles (EVs) are a heterogenous population of vesicles originate from cells. EVs are found in different biofluids and carry different macromolecules, including proteins, lipids, and nucleic acids, providing a snap shot of the parental ...
Sterghios Athanasios Moschos +8 more
core +1 more source
, 2012 Site-directed spin labeling and pulsed electron–electron double resonance (PELDOR or DEER) have previously been applied successfully to study the structure and dynamics of nucleic acids. Spin labeling nucleic acids at specific sites requires the covalent
Reginsson, Gunnar Widtfeldt +5 more
core +1 more source
Frontiers in Bioengineering and BiotechnologyIntroductionSmall membrane particles called extracellular vesicles (EVs) transport biologically active cargo between cells, providing intercellular communication.
Anastasiya Oshchepkova +15 more
doaj +1 more source
Stochastic Simulation of the Kinetics of Multiple Interacting Nucleic Acid Strands [PDF]
, 2013 DNA nanotechnology is an emerging field which utilizes the unique structural properties of nucleic acids in order to build nanoscale devices, such as logic gates, motors, walkers, and algorithmic structures. Predicting the structure and interactions of a
Schaeffer, Joseph Malcolm
core +1 more source
Clinical Microbiology Reviews, 1995 The use of nucleic acid-based vaccines is a novel approach to immunization that elicits immune responses similar to those induced by live, attenuated vaccines. Administration of nucleic acid vaccines results in the endogenous generation of viral proteins with native conformation, glycosylation profiles, and other posttranslational modifications that ...
F R, Vogel, N, Sarver
openaire +2 more sources
Characterization of Nucleic Acids and Nucleic Acid Binding Proteins Using NMR
, 2017 Biological systems are governed by molecular interactions. At the core of all biological systems is the processing of nucleic acids, and preserving the fidelity of the genome is crucial to those systems.
Evich, Marina
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Two-Holder Strategy for Efficient and Selective Synthesis of Lk 1 ssDNA Catenane
Molecules, 2018 DNA catenanes are characterized by their flexible and dynamic motions and have been regarded as one of the key players in sophisticated DNA-based molecular machines.
Qi Li +6 more
doaj +1 more source