Results 21 to 30 of about 516,976 (317)

Self-association of Coralyne: An ordered thermal destacking

Results in Chemistry, 2020
Understanding DNA-ligand interactions is a prerequisite, for designing sequence/structure specific ligands. Generally, stabilization/destabilization of DNA structures as a function of ligand is studied using UV-thermal melting, and the data is usually ...
Shikha Kaushik, Mahima Kaushik, Ritu Barthwal, Shrikant Kukreti   +3 more
doaj   +1 more source

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Molecules, 2020
Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova   +6 more
doaj   +1 more source

Redesigning nucleic acids [PDF]

Pure and Applied Chemistry, 1998
Abstract
S A, Benner, T R, Battersby, B, Eschgfaller, D, Hutter, J T, Kodra, S, Lutz, T, Arslan, D K, Baschlin, M, Blattler, M, Egli, C, Hammer, H A, Held, J, Horlacher, Z, Huang, B, Hyrup, T F, Jenny, S C, Jurczyk, M, Konig, U, von Krosigk, M J, Lutz, L J, MacPherson, S E, Moroney, E, Muller, K P, Nambiar, J A, Piccirilli, C Y, Switzer, J J, Vogel, C, Richert, A L, Roughton, J, Schmidt, K C, Schneider, J, Stackhouse   +31 more
openaire   +2 more sources

Exploring potential of i-motif DNA formed in the promoter region of GRIN1 gene for nanotechnological applications

Results in Chemistry, 2020
The tandem repeat stretches of cytosine residues fold to construct intercalated motif (i-motif) structures over an acidic pH range. Several advancements have been made to understand the biological role of i-motif DNA.
Swati Chaudhary, Mahima Kaushik, Saami Ahmed, Shrikant Kukreti   +3 more
doaj   +1 more source

Synthesis of Polyanionic C5-Modified 2′-Deoxyuridine and 2′-Deoxycytidine-5′-Triphosphates and Their Properties as Substrates for DNA Polymerases

Molecules, 2021
Modified 2′-deoxyribonucleotide triphosphates (dNTPs) have widespread applications in both existing and emerging biomolecular technologies. For such applications it is an essential requirement that the modified dNTPs be substrates for DNA polymerases. To
Claire Dutson, Esther Allen, Mark J. Thompson, Joseph H. Hedley, Heather E. Murton, David M. Williams   +5 more
doaj   +1 more source

Nanodelivery of nucleic acids

Nature Reviews Methods Primers, 2022
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented opportunity to overcome these drawbacks; owing to their tunability with diverse physico-chemical properties, they can readily be functionalized with any type of ...
Bárbara B. Mendes, João Conniot, Aviram Avital, Dongbao Yao, Xingya Jiang, Xiang Zhou, Noga Sharf-Pauker, Yuling Xiao, Omer Adir, Haojun Liang, Jinjun Shi, Avi Schroeder, João Conde   +12 more
openaire   +3 more sources

Modeling nucleic acids [PDF]

Current Opinion in Structural Biology, 2012
Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and ...
Sim, A, Minary, P, Levitt, M
openaire   +3 more sources

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

Frontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova   +7 more
doaj   +1 more source

Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies

Pharmaceutics, 2023
Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up
Carme Fàbrega, Anna Aviñó, Natalia Navarro, Andreia F. Jorge, Santiago Grijalvo, Ramon Eritja   +5 more
doaj   +1 more source

Enhanced Hybridization Selectivity Using Structured GammaPNA Probes

Molecules, 2020
High affinity nucleic acid analogues such as gammaPNA (γPNA) are capable of invading stable secondary and tertiary structures in DNA and RNA targets but are susceptible to off-target binding to mismatch-containing sequences.
Taylor D. Canady, April S. Berlyoung, Joe A. Martinez, Cole Emanuelson, Cheryl A. Telmer, Marcel P. Bruchez, Bruce A. Armitage   +6 more
doaj   +1 more source