Results 1 to 10 of about 7,787 (80)

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model [PDF]

Frontiers in Pharmacology, 2019
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases ...
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova   +7 more
doaj   +4 more sources

Site-Specific Cleavage of RNAs Derived from the PIM1 3′-UTR by a Metal-Free Artificial Ribonuclease [PDF]

Molecules, 2019
Oligonucleotide conjugates of tris(2-aminobenzimidazole) have been reported previously to cleave complementary RNA strands with high levels of sequence and site specificity.
Felix Zellmann, Laura Thomas, Ute Scheffer, Roland K. Hartmann, Michael W. Göbel   +4 more
doaj   +2 more sources

Sequence-specific RNA cleavage by PNA conjugates of the metal-free artificial ribonuclease tris(2-aminobenzimidazole) [PDF]

Beilstein Journal of Organic Chemistry, 2015
Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA).
Friederike Danneberg, Alice Ghidini, Plamena Dogandzhiyski, Elisabeth Kalden, Roger Strömberg, Michael W. Göbel   +5 more
doaj   +2 more sources

The toxin from the PemIK-Sa1 toxin-antitoxin system decreases Staphylococcus aureus resistance to antibiotics [PDF]

Frontiers in Microbiology
Toxin-antitoxin (TA) systems are bacteria-specific components involved in maintaining mobile genetic elements that may carry antibiotic resistance determinants (ARDs), among other functions.
Emilia Bonar, Kinga Chlebicka, Michał Bukowski, Michał Bukowski, Weronika Jodłowska, Maja Kosecka-Strojek, Anna Rabięcny, Piotr Suder, Małgorzata Hopciaś, Zuzanna Głowacka-Grzyb, Zuzanna Głowacka-Grzyb, Viktoria Akkerboom, Andreas Voss, Artur J. Sabat, Benedykt Władyka   +14 more
doaj   +2 more sources

Opening new frontiers with catalytic nucleic acids in miRNA inhibition [PDF]

Frontiers in Pharmacology
The concept of utilizing synthetic nucleic acids and their conjugates with biologically active molecules as RNA-targeted therapeutic agents represents a powerful strategy in the treatment of human pathologies. Recent research demonstrates that neoplastic
Olga Patutina, Svetlana Miroshnichenko, Daria Chiglintseva, Marina Zenkova   +3 more
doaj   +2 more sources

RNase T1 mimicking artificial ribonuclease [PDF]

Nucleic Acids Research, 2007
Marina Zenkova, Nadezhda Mironova, D V Pyshnyi   +2 more
exaly   +2 more sources

The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

Veterinary Sciences, 2021
Infectious bronchitis (IB) of chickens is a highly contagious disease characterized by damage of the respiratory system and reproductive organs in young animals caused by a virus of the genus Gamma coronavirus.
Ekaterina Nefedova, Vyacheslav Koptev, Anna S. Bobikova, Viktoria Cherepushkina, Tatyana Mironova, Vasily Afonyushkin, Nikolai Shkil, Nikolai Donchenko, Yulia Kozlova, Natalia Sigareva, Natalia Davidova, Nina Bogdanchikova, Alexey Pestryakov, Yanis Toledano-Magaña   +13 more
doaj   +1 more source

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

Molecules, 2021
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova   +7 more
doaj   +1 more source

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

Molecules, 2020
Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina, Daria Chiglintseva, Elena Bichenkova, Svetlana Gaponova, Nadezhda Mironova, Valentin Vlassov, Marina Zenkova   +6 more
doaj   +1 more source

A Trisbenzimidazole Phosphoramidite Building Block Enables High-Yielding Syntheses of RNA-Cleaving Oligonucleotide Conjugates

Molecules, 2020
The RNA cleaving catalyst tris(2-aminobenzimidazole) when attached to the 5’ terminus of oligonucleotides cuts complementary RNA strands in a highly site-specific manner.
Felix Zellmann, Michael W. Göbel
doaj   +1 more source