Results 21 to 30 of about 1,576,930 (245)
Target-directed catalytic metallodrugs
Brazilian Journal of Medical and Biological Research, 2013 Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets.
J.C. Joyner, J.A. Cowan
doaj +1 more source
The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition [PDF]
, 2008 The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3’ specific exo-ribonucleases involved in the degradation of the ...
Naohiro Kobayashi +25 more
core +2 more sources
Site-selective artificial ribonuclease using pinpoint RNA activation [PDF]
Nucleic Acids Symposium Series, 2001 An acridine residue attached to the end or the inside of a DNA activates the target phosphodiester linkages in complementary RNA. Due to this pinpoint activation, the RNA is site-selectively and efficiently cleaved at these linkages by various free metal ions under mild condition.
A, Kuzuya, R, Mizoguchi, M, Komiyama
openaire +2 more sources
Enhanced RNA cleavage within bulge-loops by an artificial ribonuclease [PDF]
Nucleic Acids Research, 2005 Cleavage of phosphodiester bonds by small ribonuclease mimics within different bulge-loops of RNA was investigated. Bulge-loops of different size (1-7 nt) and sequence composition were formed in a 3' terminal fragment of influenza virus M2 RNA (96 nt) by hybridization of complementary oligodeoxynucleotides. Small bulges (up to 4 nt) were readily formed
Kuznetsova, Irina L. +3 more
openaire +2 more sources
Identification and analysis of S-genotypes in 23 new pear cultivars [PDF]
Guoshu xuebao[Objective] Taxonomically, pear (Pyrus spp.) belongs to the Rosaceae family, Maloideae subfamily and Pyrus genus. It exhibits a typical gametophytic self-incompatibility (GSI) mechanism controlled by a single S-locus with multiple alleles.
WANG Yanan +5 more
doaj +1 more source
Design and Synthesis of Peptide-Oligonucleotide Conjugates as Potential Artificial Ribonucleases [PDF]
Nucleic Acids Symposium Series, 2008 A series of peptide-oligonucleotide conjugates was synthesized. The peptide fragment was attached to the middle part of DNA sequence. For this purpose the new amidophosphite dC with linker at C5-position was synthesized.
Inna, Serpokrylova +4 more
openaire +2 more sources
Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly
, 2019 Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein.
Junpei Ota (8257518) +4 more
core +1 more source
Synthetic in vitro transcriptional oscillators
Molecular Systems Biology, 2011 The construction of synthetic biochemical circuits from simple components illuminates how complex behaviors can arise in chemistry and builds a foundation for future biological technologies.
Jongmin Kim, Erik Winfree
doaj +1 more source
A novel biological actions acquired by ribonuclease through oligomerization
, 2008 After a short introduction with some examples of cytotoxic ribonucleases, the importance of natural or artificial dimerization (oligomerization) as a way for a ribonuclease to acquire novel functional properties has been pointed out.
LIBONATI, Massimo +2 more
core +1 more source
Journal of Nucleic Acids, 2011 Design of site-selective artificial ribonucleases (aRNases) is one of the most challenging tasks in RNA targeting. Here, we designed and studied oligonucleotide-based aRNases containing multiple imidazole residues in the catalytic part and systematically
Natalia G. Beloglazova +6 more
doaj +1 more source